Blood tests in the ambulance: a new study probes early brain injury markers
NCT ID NCT07782216
First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time
Summary
This study looks at whether specific proteins released into the blood after a traumatic brain injury or cardiac arrest can help doctors assess damage and predict recovery. Researchers will collect blood samples from patients starting in the ambulance or emergency department and continue over the first 24 hours. By tracking how these proteins change over time, they hope to find the most reliable early indicators of brain injury severity and long-term outcome.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- No experimental treatment; the study observes standard care and measures protein biomarkers in blood samples.
- What this could lead to
- If successful, this could identify which blood proteins best predict brain injury severity and outcomes, potentially guiding faster, more accurate emergency treatment decisions.
- What could go wrong
- This is an observational study, so it won't test a new treatment. Biomarker levels may vary widely between patients, and findings may not translate into immediate clinical changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 477 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adults aged 18 years or older presenting to emergency departments or prehospital emergency services in Hungary with acute brain injury (traumatic brain injury or cardiac arrest). Participants are enrolled consecutively at emergency departments, intensive care units, and by the Hungarian National Ambulance Service across multiple regions of Hungary.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Age 18 years or older (all arms) * Polytraumatized patients categorized as T1 triage by the first responder based on injury mechanism and/or sustained injuries, with intubation indicated by the first responder (Arm 1) * Cardiac arrest treated in the prehospital setting (Arm 2) * Severe traumatic brain injury enrolled at hospital admission (Arm 3) Exclusion Criteria (all arms) * Age under 18 years * Pre-existing neurological or psychiatric conditions * Hypothermia or hyperthermia at the time of enrollment * Pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hungarian National Ambulance Service
RECRUITINGBudapest, Pest County, 1055, Hungary
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North Pest Central Hospital - Military Hospital, Emergency Centre
RECRUITINGBudapest, Pest County, 1134, Hungary
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Petz Aladár University Teaching Hospital, Emergency Department
RECRUITINGGyőr, Győr-Moson-Sopron, 9024, Hungary
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University of Pécs Clinical Center, Department of Emergency Medicine
RECRUITINGPécs, Branya, 7624, Hungary
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