Blood tests in the ambulance: a new study probes early brain injury markers

NCT ID NCT07782216

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This study looks at whether specific proteins released into the blood after a traumatic brain injury or cardiac arrest can help doctors assess damage and predict recovery. Researchers will collect blood samples from patients starting in the ambulance or emergency department and continue over the first 24 hours. By tracking how these proteins change over time, they hope to find the most reliable early indicators of brain injury severity and long-term outcome.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
No experimental treatment; the study observes standard care and measures protein biomarkers in blood samples.
What this could lead to
If successful, this could identify which blood proteins best predict brain injury severity and outcomes, potentially guiding faster, more accurate emergency treatment decisions.
What could go wrong
This is an observational study, so it won't test a new treatment. Biomarker levels may vary widely between patients, and findings may not translate into immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 477 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18 years or older presenting to emergency departments or prehospital emergency services in Hungary with acute brain injury (traumatic brain injury or cardiac arrest). Participants are enrolled consecutively at emergency departments, intensive care units, and by the Hungarian National Ambulance Service across multiple regions of Hungary.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Age 18 years or older (all arms) * Polytraumatized patients categorized as T1 triage by the first responder based on injury mechanism and/or sustained injuries, with intubation indicated by the first responder (Arm 1) * Cardiac arrest treated in the prehospital setting (Arm 2) * Severe traumatic brain injury enrolled at hospital admission (Arm 3) Exclusion Criteria (all arms) * Age under 18 years * Pre-existing neurological or psychiatric conditions * Hypothermia or hyperthermia at the time of enrollment * Pregnancy

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia Brain Injuries, Traumatic brain injury cardiac arrest Hypoxia, Brain Out-of-Hospital Cardiac Arrest traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hungarian National Ambulance Service

    RECRUITING

    Budapest, Pest County, 1055, Hungary

  • North Pest Central Hospital - Military Hospital, Emergency Centre

    RECRUITING

    Budapest, Pest County, 1134, Hungary

  • Petz Aladár University Teaching Hospital, Emergency Department

    RECRUITING

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • University of Pécs Clinical Center, Department of Emergency Medicine

    RECRUITING

    Pécs, Branya, 7624, Hungary

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