CARDIAC ARREST (CA)

This study tests a new device called NEURESCUE, a balloon that is inserted into a leg artery and inflated to send more blood to the heart and brain during cardiac arrest. About 84 adults with witnessed cardiac arrest and a non-shockable heart rhythm will be randomly assigned to r…

This study tests whether adding a small amount of air pressure (called PEEP) to the breathing tube during CPR helps restart the heart and improves survival in adults whose heart stops outside a hospital. About 132 participants will be randomly assigned to receive either standard …

This study tests whether starting a heart-lung machine (ECMO) right at the scene of a cardiac arrest, instead of waiting until the hospital, can improve survival and brain function. About 90 adults under 70 with witnessed cardiac arrest and bystander CPR will be enrolled. The goa…

This study tests a specific way of helping children breathe during CPR after a cardiac arrest. The goal is to see if this method helps more children survive and have good brain function. About 1,530 children who need CPR and a breathing tube will take part.

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest. The scan uses existing images and special software, so no extra medications or monitoring are needed. Researchers will compare the CT results with the standard inv…

This study tests a new therapy called AMBET for treating PTSD in people who survived a cardiac arrest. About 90 participants will receive either AMBET or another therapy (PCT) over 12 weeks. The goal is to see which therapy better reduces PTSD symptoms and improves daily life.

This study is testing two short mind-body programs for people who survived a cardiac arrest and the family or friends who care for them. The goal is to see if these programs are practical and helpful for reducing anxiety, depression, and emotional distress. About 84 pairs (surviv…

This study compares a mixed reality (MR) CPR training system called HEROS 4.0 to standard instructor-led classes. 120 adults aged 18-50 who haven't had CPR training in the last year will participate. The goal is to see if MR training is as effective as traditional methods for lea…

This study follows 12 cardiac arrest survivors for 5 years to see how they are doing after receiving ultra-rapid cooling treatment. The cooling was done using a special system that lowers body temperature quickly to protect the brain and heart. Researchers will check if participa…

This study will follow 10,000 people with heart conditions (like heart failure, heart attack, or bypass surgery) who are going through cardiac rehab at a clinic in Davos, Switzerland. Researchers will collect health data, blood samples, and patient reports to learn what helps peo…

This study follows 3,500 adults who survived a cardiac arrest to see how different hospital treatments (sedation, temperature control, and blood pressure management) impact their kidneys. Researchers will measure kidney failure, need for dialysis, and long-term kidney function. T…

This study looks at 50 adults who had a cardiac arrest and are in the intensive care unit. Researchers will use advanced blood tests and brain ultrasounds to see if they can better predict how well the brain will recover. The goal is to help doctors make more informed decisions a…

This study watches how breathing support (ventilation) is given during CPR for adults whose heart stops in the hospital. It aims to find which air volume and breathing rate work best to restart the heart. Researchers will compare different ventilation levels to see which leads to…

This study aims to improve how emergency call operators identify life-threatening conditions like heart attack, stroke, and breathing problems over the phone. Researchers will analyze millions of past emergency calls using artificial intelligence to find patterns that help spot s…

This study looks at the spinal fluid of 60 people who had a cardiac arrest to find out what causes additional brain damage. Researchers will analyze the fluid's genes, proteins, and other molecules to identify key changes. The goal is to use this information to discover new drug …

This study looks at how often the airway closes during CPR in people who have a cardiac arrest outside the hospital. Researchers will analyze breathing data from 150 patients to see if a new measurement, called the Airway Opening Index, can help predict whether the heart will res…

This study looks at whether long-term stress plays a role in cardiac arrest. Researchers will measure the stress hormone cortisol in hair samples from 136 adults who had a cardiac arrest or heart attack. The goal is to see if higher stress levels are linked to worse outcomes afte…

This study tests whether special phone instructions that focus on using an AED (defibrillator) can help bystanders perform better CPR. About 80 volunteers will act as rescuers in a simulated cardiac arrest. The goal is to reduce pauses in chest compressions and improve the chance…

This study watches 250 adults who remain unconscious after a cardiac arrest to see if early brain tests can predict when they will wake up. Researchers use EEG, pupil checks, and ultrasound to find clues. The goal is to help doctors know sooner who will recover, but this study do…

This study looks for genetic causes of out-of-hospital cardiac arrest in people aged 18-50 in Lombardy, Italy. Researchers will analyze blood samples from 1,725 patients to find inherited heart disease genes. They will also check family members to help prevent future sudden cardi…

This study looks for brain injury in patients who remain unresponsive after a cardiac arrest. Researchers will use a portable MRI scanner at the bedside to take multiple images over several days. The goal is to understand how brain injury changes over time and to find signs that …