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Could a tiny valve boost survival after cardiac arrest?

NCT ID NCT06939335

Recruiting now Disease control Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a small valve (PEEP) to the breathing bag during CPR helps restart the heart and improve survival in adults whose heart stops outside a hospital. About 132 participants will be randomly assigned to receive CPR with or without PEEP. The goal is to see if this simple change leads to better outcomes, including survival with good brain function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Positive End-Expiratory Pressure (PEEP) via a disposable valve set at 5 cm H2O
What this could lead to
If it works, this could improve survival and brain function after cardiac arrest by keeping airways open during CPR.
What could go wrong
This is a small, early-phase trial (132 participants), so results may not apply broadly. PEEP may also increase chest pressure or cause lung injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest sudden cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST (CA) OUT-OF-HOSPITAL CARDIAC ARREST (OHCA) POSITIVE END-EXPIRATORY PRESSURE (PEEP) VENTILATION DURING RESUSCITATION

Contacts and locations

Locations

  • AZ Oostende

    RECRUITING

    Ostend, West-Flandres, 8400, Belgium

  • AZ Zeno

    RECRUITING

    Knokke, 8300, Belgium

    Contact Email: •••••@•••••

  • AZORG: Campus Moorselbaan

    RECRUITING

    Aalst, B-9300, Belgium

  • AZORG: campus Geraardsbergen

    RECRUITING

    Geraardsbergen, B-9500, Belgium

  • AZORG: campus Merestraat

    RECRUITING

    Aalst, B-9300, Belgium

  • Centre hospitalier universitaire (CHU) Besançon-Franche-Comté

    ACTIVE_NOT_RECRUITING

    Besançon, France

  • UZ Ghent

    RECRUITING

    Ghent, B-9240, Belgium

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