CARDIAC ARREST (CA)

This study tests whether giving a TNF-alpha blocker within 6 hours of restarting the heart can improve survival and brain recovery in patients who remain unconscious after cardiac arrest. The drug aims to calm the body's harmful inflammatory response. About 208 adults with suspec…

This study tests whether using a device to precisely control breathing during CPR improves outcomes for adults who have a cardiac arrest in the hospital. About 852 participants will be randomly assigned to either standard manual breathing or breathing guided by real-time feedback…

This study tests a new CPR method called Bio-CPR, which synchronizes chest compressions with breathing support, for adults who have a cardiac arrest outside the hospital. Researchers will compare Bio-CPR to standard CPR in 408 patients to see if it improves breathing and oxygen l…

This study tests a drug called GC7 in 20 adults who recently had a cardiac arrest and were revived. The goal is to see if GC7 can reduce harmful oxidative stress and inflammation that often lead to organ damage. This is an early-stage human trial, so the main focus is safety and …

This study looks at whether a new rapid blood test, done right at the patient's bedside, can help predict which critically ill patients are at higher risk of dying within 30 days. The test measures a substance called nucleosomes in the blood. Researchers will compare this quick t…

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and whether a computer program could suggest better ventilator settings. No new treatments are given—the team will rev…

This study looks at whether sending people who survive a cardiac arrest outside the hospital to a specialized cardiac arrest center helps them recover better. About 1,618 adults will be randomly assigned to either a specialized center or the nearest hospital. Researchers will che…

This study looks at 200 adults who had a cardiac arrest and were successfully revived. About a day later, doctors will use a small camera to check the colon for damage. The goal is to learn how common colon ischemia is after CPR, which could help improve future care.

This study tests whether a portable, very low-field MRI can detect brain damage in coma patients after cardiac arrest as well as standard high-field MRI does. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two weeks. The goa…

This study will collect information from 1,200 patients in the French West Indies and Guiana who receive ECMO, a machine that helps the heart and lungs work. The goal is to learn how well ECMO works and what problems may occur. No new treatments are being tested; instead, researc…