Could a 2-Second longer pause in CPR save more hearts?

NCT ID NCT06824961

Recruiting now Disease control Sponsor: Amsterdam UMC, location VUmc Source: ClinicalTrials.gov ↗

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests whether extending the compression pause from 3 to 5 seconds during mechanical CPR helps rescuers deliver two effective breaths more often. It includes adults who had a cardiac arrest outside the hospital and were treated with a LUCAS device. The study compares the percentage of pauses where both breaths are given, and also looks at whether the heart restarts and survival with good brain function improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mechanical CPR with a 5-second ventilation pause
What this could lead to: If a longer pause helps, it could improve ventilation and increase the chance of restarting the heart during cardiac arrest, potentially saving more lives.
What could go wrong: The trial is early and results may not show a clear benefit. Longer pauses might reduce blood flow during compressions, and outcomes depend on many factors beyond pause duration.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARDIAC ARREST (CA) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST (CA)

Contacts and locations

Locations

Ambulance Amsterdam
RECRUITING

Amsterdam, North Holland, 1075LB, Netherlands
Regionale Ambulance Voorziening Kennemerland - Ambulancezorg GGD Kennemerland
RECRUITING

Haarlem, North Holland, 2015CK, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.