HYPERCAPNIA

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study compares a new asymmetric nasal cannula (DUET) to a standard one in 50 people with mild-to-moderate COPD flare-ups and high carbon dioxide levels. Each participant will try both devices for 3 hours to see which lowers CO2 better, reduces breathing effort, and feels mor…

This study looks at whether changing the amount of carbon dioxide (CO2) in a child's breath during anesthesia affects how deeply asleep they are. Researchers will adjust CO2 levels in 100 children aged 3-11 and measure brain activity with a monitor. The goal is to see if higher C…

This study follows 25 people with COPD and high carbon dioxide levels who use a breathing machine at night. Researchers want to see if nighttime breathing problems can predict how well the machine works over 6 to 12 months. They will also check lung function, diaphragm health, an…

This study looks at what makes scuba divers more likely to suffer from oxygen toxicity, which can cause seizures. Researchers will test how breathing muscle training, lack of sleep, common medications, and carbon dioxide affect risk. About 62 healthy adults aged 18-45 will exerci…