Caffeine dosing study for newborns with HIE aims to improve safety

NCT ID NCT06448780

Ongoing Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective amount. The goal is to better understand how to use caffeine to help these newborns.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia perinatal asphyxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOXIC-ISCHEMIC ENCEPHALOPATHY

Contacts and locations

Locations

Novant Health New Hanover Regional Medical Center

Wilmington, North Carolina, 28401, United States
The University of North Carolina at Chapel Hill Newborn Critical Care Center

Chapel Hill, North Carolina, 27599, United States

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