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Simple cord milking procedure could protect newborn brains after difficult births

NCT ID NCT03682042

Disease control Sponsor: Nemours Children's Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK trial, assessing their thinking, movement, vision, and hearing at ages 1 and 2. The goal is to see if this simple, low-cost step reduces the risk of long-term disabilities compared to standard early cord clamping.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Umbilical cord milking (a procedure where blood in the cord is pushed toward the baby before clamping)
What this could lead to
If effective, this simple, low-cost procedure could reduce the risk of brain injury and long-term disability in newborns who are limp or not breathing well at birth.
What could go wrong
This is a follow-up study; the main trial results are not yet known. The procedure may not improve outcomes, and there is a small risk of complications from the milking itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 3,442 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 26 months

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Enrolled in CORDMILK trial * Non-vigorous at birth Exclusion Criteria: * None

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia perinatal asphyxia twin to twin transfusion syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Birth asphyxia Hypoxic-ischemic encephalopathy

Contacts and locations

Locations

  • All India Institute of Medical Science

    Nagpur, MS, 441108, India

  • Daga Memorial Woman and Children Hospital

    Nagpur, MS, 440002, India

  • Government Medical College

    Chandrapur, MS, 442401, India

  • Government Medical College and Hospital

    Nagpur, MS, 440009, India

  • Indira Gandhi Government Medical College & Hospital

    Nagpur, Maharashtra, 440018, India

  • KLE Academy of Higher Education and Research (Deemed-to-be-University) Jawaharlal Nehru Medical College

    Belagavi, Karnataka, 590010, India

  • Mahatma Gandhi Institute of Medical Sciences/ Kasturba Hospital

    Wardha, MS, 442102, India

  • Pimpri Chinchwad Municipal Corporation's Post-Graduate Institute, Yashwantrao Chavan Memorial Hospital

    Pune, Maharashtra, 411018, India

  • Sawai Man Singh (SMS) Medical College

    Jaipur, Rajasthan, 302004, India

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