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Simple cord milking procedure could protect newborn brains after difficult births

NCT ID NCT03682042

Ongoing Disease control Sponsor: Nemours Children's Clinic Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK trial, assessing their thinking, movement, vision, and hearing at ages 1 and 2. The goal is to see if this simple, low-cost step reduces the risk of long-term disabilities compared to standard early cord clamping.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Umbilical cord milking (a procedure where blood in the cord is pushed toward the baby before clamping)
What this could lead to
If effective, this simple, low-cost procedure could reduce the risk of brain injury and long-term disability in newborns who are limp or not breathing well at birth.
What could go wrong
This is a follow-up study; the main trial results are not yet known. The procedure may not improve outcomes, and there is a small risk of complications from the milking itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia perinatal asphyxia twin to twin transfusion syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIRTH ASPHYXIA HYPOXIC-ISCHEMIC ENCEPHALOPATHY

Contacts and locations

Locations

  • All India Institute of Medical Science

    Nagpur, MS, 441108, India

  • Daga Memorial Woman and Children Hospital

    Nagpur, MS, 440002, India

  • Government Medical College

    Chandrapur, MS, 442401, India

  • Government Medical College and Hospital

    Nagpur, MS, 440009, India

  • Indira Gandhi Government Medical College & Hospital

    Nagpur, Maharashtra, 440018, India

  • KLE Academy of Higher Education and Research (Deemed-to-be-University) Jawaharlal Nehru Medical College

    Belagavi, Karnataka, 590010, India

  • Mahatma Gandhi Institute of Medical Sciences/ Kasturba Hospital

    Wardha, MS, 442102, India

  • Pimpri Chinchwad Municipal Corporation's Post-Graduate Institute, Yashwantrao Chavan Memorial Hospital

    Pune, Maharashtra, 411018, India

  • Sawai Man Singh (SMS) Medical College

    Jaipur, Rajasthan, 302004, India

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