Twin to twin transfusion syndrome
MONDO:0019805Twin twin transfusion syndrome (TTTS) is a rare condition seen in twin monochorionic pregnancies, typically developing during the 15-26 week gestation period and usually due to unbalanced intertwin placental anastomoses, where an unequal exchange of blood between twins causes oligohydramnios in one sac and polyhydramnios in the other which can lead to a high perinatal mortality rate and a high rate of disability in survivors if left untreated
Also known as: Feto-fetal transfusion syndrome, Twin Anemia Polycythemia Sequence, Twin-Twin transfusion syndrome, foetal blood loss from foetal haemorrhage into co-twin, foetal haemorrhage into co-twin, placental transfusion syndrome, stuck Twin syndrome, twin-to-twin transfusion syndrome
21 clinical trials for this condition and its sub-types.
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Broader categories
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Simple cord milking procedure could save preterm Infants' lives
Disease control Recruiting nowThis trial compares two ways of managing the umbilical cord right after birth in preterm infants (30-34 weeks) who are not vigorous. One method, umbilical cord milking, involves pushing blood from the cord toward the baby before clamping. The other is early cord clamping. The stu…
Phase: NA • Sponsor: Nemours Children's Clinic • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Waiting to clamp the cord: could 30 seconds save preterm babies?
Disease control Recruiting nowThis study compares delayed cord clamping (waiting at least 30 seconds after birth) with immediate clamping in preterm infants born between 32 and 37 weeks. The goal is to see if the extra time improves early health outcomes such as breathing, anemia risk, and survival. Researche…
Phase: NA • Sponsor: Faculty of Medicine of Tunis • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Cord blood boost: new study aims to help tiniest newborns
Disease control Recruiting nowThis study looks at three methods of giving premature babies (born at 32 weeks or earlier) extra blood from the placenta right after birth: intact cord milking, cut-cord milking, and delayed cord clamping. Researchers want to see which method best improves the baby's blood health…
Phase: NA • Sponsor: Alexandria University • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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New anemia drug enters early human testing
Symptom relief Recruiting nowThis early-stage study tests a new drug called APG-5918 in healthy volunteers and people with anemia (low red blood cells). The main goal is to check safety and how the body handles the drug, while also seeing if it can raise hemoglobin levels. About 105 participants will take pa…
Phase: PHASE1 • Sponsor: Ascentage Pharma Group Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Hospital tests if its own anemia rules actually get followed
Knowledge-focused Recruiting nowThis study looks at whether doctors at Siriraj Hospital follow a new guideline for treating anemia in patients before major surgery. Anemia is common in surgical patients and can lead to more blood transfusions and worse outcomes. The researchers will track 93 anemic patients to …
Sponsor: Siriraj Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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New fetal heart monitor could unlock secrets of stillbirth
Knowledge-focused Recruiting nowThis study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…
Sponsor: Medical College of Wisconsin • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Twin surgery study: which entry method is safer?
Knowledge-focused Recruiting nowThis study looks at two common techniques surgeons use to enter the uterus during laser surgery for twin-to-twin transfusion syndrome. The goal is to see if one method causes less separation of the membrane around the baby. About 216 pregnant women with this condition will take p…
Phase: NA • Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Anemia type may predict surgery danger
Knowledge-focused Recruiting nowThis study is observing 1000 adults having moderate- to high-risk surgery to see if the type and severity of anemia they have before surgery affects their risk of complications like heart injury, kidney injury, or stroke. Researchers will compare patients with iron-deficiency ane…
Sponsor: Peking Union Medical College Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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AI could revolutionize heart valve surgery predictions
Knowledge-focused Recruiting nowThis study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…
Sponsor: Montreal Heart Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC