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Could a nerve-stimulation device help the brain learn again after a stroke?

NCT ID NCT07719387

Knowledge-focused Sponsor: Stony Brook University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study tests whether pairing vagus nerve stimulation (VNS) with language training can improve memory and learning in people who have already used VNS for movement recovery after a stroke. Participants, who already have a VNS implant, will try learning a new language while the device is active. The goal is to see if VNS can also support cognitive recovery, not just motor recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vagus nerve stimulation (VNS) paired with cognitive training
What this could lead to
If it works, this could point toward a new way to enhance cognitive recovery and language learning after stroke.
What could go wrong
This is a very small, early study with only 20 participants who already have a VNS device. Results may not apply to all stroke survivors, and the cognitive benefits of VNS are still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 22 years or older * History of stroke * Implanted with a Vivistim™ VNS device * Monolingual in English * Home-dwelling and independent in activities of daily living * No prior language training in the selected language of learning * Tolerated 6 weeks of movement therapy at 0.8 mA without incident and has used the device for at-home stimulation without incident * Willing and able to participate in a six-week at-home intervention * Clinically stable, without major concurrent medical conditions that would interfere with study participation Exclusion Criteria: * Severe aphasia * Unable to read and/or write in English * Significant uncorrected hearing or visual impairment * Unable to commit to 6 weeks of therapy * Pregnancy * Prisoner or ward of the state * Any medical condition that, in the investigator's judgment, would make participation unsafe * Younger than 22 years of age

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Conditions

The condition(s) this trial relates to.

cognitive disorder stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive assessment Language acquisition Stroke Vagus nerve stimulation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Stony Brook University Hospital

    Stony Brook, New York, 11790, United States

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