New hope for young brain tumor patients: chemotherapy first, then targeted radiation
NCT ID NCT00602667
First seen Jan 17, 2026 · Last updated Jun 19, 2026 · Updated 23 times
Summary
This clinical trial tests a risk-adapted approach for young children with newly diagnosed brain tumors. The treatment starts with chemotherapy to delay radiation, giving the brain more time to develop. Then, radiation is carefully targeted to the tumor area to reduce side effects on thinking and learning. The study includes children with several tumor types, such as medulloblastoma and high-grade glioma, and aims to improve survival while protecting brain function.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Hospitals and Clinics of Minnesota - St. Paul
Saint Paul, Minnesota, 55102, United States
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Lady Cilento Children's Hospital, Brisbane
Brisbane, Queensland, 4029, Australia
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Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304, United States
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Rady Children's Hospital
San Diego, California, 92123, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75390, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
chemotherapy (methotrexate, vincristine, cisplatin, cyclophosphamide) and radiation therapy
What this could lead to
If successful, this approach could improve survival rates for young children with brain tumors while reducing long-term thinking and learning problems.
What could go wrong
This is a Phase 2 trial, so results are still preliminary. The combination of chemotherapy and radiation may still cause side effects, and not all tumor types may respond equally.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.