Can the Body's own immune cells beat a recurrent brain tumor?
NCT ID NCT01326104
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether giving patients their own tumor-specific immune cells, along with a dendritic cell vaccine, can help fight recurrent medulloblastoma or primitive neuroectodermal tumors. Participants receive these treatments after high-dose chemotherapy and a stem cell transplant. The goal is to see if this approach can improve progression-free survival at 12 months compared to historical benchmarks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tumor-specific T cells (TTRNA-xALT) and dendritic cell vaccines (TTRNA-DCs)
- What this could lead to
- If successful, this approach could offer a new way to fight recurrent brain tumors in children, potentially improving survival and pointing toward a cure.
- What could go wrong
- This is an early-phase trial with a small number of patients, so results may not be conclusive. The treatment involves intensive chemotherapy and stem cell transplant, which carry significant risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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University of Florida
Gainesville, Florida, 32610, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can trained immune cells outsmart brain tumors?
- Can AI read tumor slides to outsmart childhood cancer?
- Could an antiparasitic drug boost radiation against childhood brain tumors?
- AI reads MRI scans to reveal hidden brain tumor types in children before surgery
- Scientists probe MYC gene's weak spots in aggressive childhood brain cancer
- Parental distress may undermine treatment in children with recurrent brain tumors