MEDULLOBLASTOMA

This study tests whether digoxin, a common heart medication, can help children and young adults (ages 1 to 29) with a specific type of relapsed brain cancer called non-WNT/non-SHH medulloblastoma. Participants must have already had chemotherapy and radiation. The main goal is to …

This study tests a combination of two drugs—Lutathera (a targeted radiation therapy) and olaparib (a PARP inhibitor)—in children and teens aged 3 to 18 with solid tumors that have come back or not responded to standard treatment. The goal is to find the safest dose and see if the…

This study tests a new drug called Becotatug Vedotin in children aged 2 to 18 with certain cancers (like head and neck, brain, or kidney tumors) that have come back or spread. The drug targets a protein called EGFR found on many cancer cells. The main goal is to see if the drug i…

This study is testing a drug called Lutathera in people aged 4 to 39 with certain aggressive brain tumors or meningiomas that have come back or are growing. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dose…

This study tests a new combination of drugs for children and young adults (ages 6–25) with brain cancers like medulloblastoma or glioblastoma that have come back or not responded to treatment. The goal is to find a safe dose of ibrutinib when added to an immunotherapy drug (indox…

This study offers expanded access to the drug DFMO for children and young adults (ages 0-30) with rare, relapsed tumors like neuroblastoma and medulloblastoma. The drug targets tumors with specific genetic markers (LIN28, MYCN, or ODC). The goal is to provide treatment when no ot…

This early-stage trial tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and understand side effects. About 102 participants will receive the drug weekly or multiple days per week.

This early-stage trial tests a new treatment for children and young adults (up to age 21) with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a p…

This study tests whether customizing treatment based on the tumor's genetic makeup can improve outcomes for children under 5 with medulloblastoma, a type of brain cancer. About 130 participants will receive different combinations of chemotherapy and radiation depending on their r…

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, especially those with changes in the MYC or MYCN genes. The goal is to see if the drug can shrink tumors or stop them from growing. Participants receive the drug through an IV every 3 weeks for up t…

This study tests a drug called DFMO as a maintenance therapy to prevent cancer from coming back in children with high-risk medulloblastoma. The trial enrolls 118 participants aged 0-21 who have molecular high-risk, very high-risk, or relapsed/refractory disease. Researchers will …

This early-phase trial tests a new treatment for children and young adults with medulloblastoma or similar brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack…

This study is testing whether a special type of PET/MRI scan (using a radioactive tracer called 68Ga-DOTATATE) can better detect brain tumors, especially meningiomas, and tell the difference between tumor regrowth and changes from previous treatment. About 200 adults with certain…

This study follows 184 people who survived medulloblastoma (a type of brain tumor) after receiving radiation therapy to the brain and spine. Researchers want to learn about long-term health problems like memory issues, hearing loss, heart and hormone problems, and physical fitnes…

This study is testing a new approach for children and young adults whose medulloblastoma or ependymoma has come back. After surgery, the tumor is quickly tested in the lab and its genes are analyzed to find the most effective and least toxic drugs for that specific patient. A spe…