MEDULLOBLASTOMA

This early-stage study is testing a new antibody drug called APX005M in children and young adults with brain tumors that have come back or are not responding to treatment, or with a newly diagnosed aggressive brain stem glioma. The main goal is to find the safest dose and underst…

This early-stage study is testing the safety of a new cell therapy for adults with aggressive brain cancers that have spread to the lining of the brain and spinal cord. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cell…

This study is testing whether lower doses of radiation to the brain and spine, along with reduced chemotherapy, can still effectively treat children with a specific type of brain tumor called WNT-driven medulloblastoma. The goal is to maintain a high cure rate while significantly…

This early-stage study is testing a new treatment for children and young adults whose brain or spinal cord tumors have come back or haven't responded to standard therapies. Doctors collect the patient's own immune cells, modify them in a lab to recognize and attack cancer cells, …

This study is testing a cancer vaccine called SurVaxM in children and young adults with aggressive brain tumors that have come back or progressed. The vaccine is designed to teach the body's immune system to find and destroy cancer cells that carry a specific protein called survi…

This study is testing a new, personalized approach to treating medulloblastoma, a type of brain cancer in children. Doctors will analyze each child's tumor to determine its genetic type and risk level, then assign a specific combination of surgery, radiation, and chemotherapy. Th…

This study aims to find the best treatment for children under 10 with aggressive brain tumors like medulloblastoma. It compares a single intensive chemotherapy cycle against three back-to-back cycles after initial treatment, to see which approach better controls the cancer and im…

This study is testing whether adding an immunotherapy drug called indoximod to standard chemotherapy and radiation can better control aggressive brain tumors in children and young adults. It is for patients aged 3 to 21 with certain progressive brain cancers or a newly diagnosed,…

This study is testing a new type of imaging scan to see if it can better detect and monitor tumors in children and young adults with cancer. The scan uses a radioactive form of a natural protein building block called methionine. Researchers want to see how well this new scan work…

This study aims to understand how radiation therapy for brain tumors causes inflammation in the brain. Researchers will use special PET scans and optional MRI scans on 22 children with medulloblastoma to measure this inflammation over two years. The goal is to learn how this infl…