MEDULLOBLASTOMA

This early-phase study tests whether specially engineered immune cells (CAR T cells) can safely target and destroy brain tumor cells that have spread to the lining of the brain and spinal cord. Ten adults with glioblastoma, ependymoma, or medulloblastoma will receive these cells.…

This study tests whether giving lower doses of radiation and chemotherapy to children with a specific type of brain tumor (WNT medulloblastoma) can still cure the cancer while reducing long-term side effects like learning problems and hormone issues. About 45 children aged 3 to 2…

This study tests a personalized approach for children and young adults with newly diagnosed medulloblastoma, a type of brain tumor. Treatment—including surgery, radiation, and chemotherapy—is tailored based on the tumor's molecular subtype and how much cancer remains after surger…

This study tests whether adding the drug indoximod to standard chemotherapy and radiation can help children aged 3 to 21 with certain brain cancers. The drug aims to boost the body's immune system to fight tumors more effectively. The trial includes children with progressive glio…

This early-stage study tests a flavored, drinkable chemotherapy called VAL-413 (Orotecan) combined with another drug (temozolomide) in children and young adults up to age 30 whose solid tumors have come back. The main goal is to find the safest dose and see how the body processes…

This early-phase study tests a cancer vaccine called SurVaxM in 35 children with brain tumors that have come back or are hard to treat. The vaccine is designed to teach the body's immune system to find and destroy tumor cells carrying a protein called survivin. The goal is to see…

This early-stage trial tests the safety and best dose of a drug called APX005M in 32 children whose brain tumors have come back or are hard to treat, including a type of brain stem tumor called DIPG. The drug works by activating the immune system to attack cancer cells. The main …

This early-stage study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The cells are…

This study tests whether giving three rounds of high-dose chemotherapy with stem cell rescue works better than one round for children under 10 with high-risk brain tumors. The goal is to improve survival without adding too many side effects. About 250 children will take part, and…

This study tests a new type of PET/CT scan that uses a radioactive tracer called 68Ga-DOTATOC to find neuroendocrine tumors (NETs) and other related cancers. The scan targets a molecule found in high amounts on these tumor cells. Researchers want to see if this scan is safer and …

This study looks at whether a special PET scan using a natural substance called methionine can help doctors see tumors in children and young adults with cancer. About 500 participants will get the scan to check if it can find tumors, tell how aggressive they are, and tell leftove…

This study uses a special PET scan to measure brain inflammation caused by radiation therapy in children with medulloblastoma. About 22 participants will be scanned before, during, and up to two years after treatment. The goal is to understand how radiation affects different brai…