MEDULLOBLASTOMA

This study is testing a drug called liothyronine (L-T3), both alone and combined with standard chemotherapy, for children and young adults whose medulloblastoma brain cancer has come back or gotten worse after initial treatment. The first part of the trial aims to find a safe dos…

This study is testing a personalized approach to find treatments for brain tumors that have stopped responding to standard therapies. Doctors will test tumor cells from surgery in a lab to see which drugs might work best for each patient. The goal is to see if this 'drug-matching…

This study is testing a new combination treatment for children and young adults with aggressive brain cancers that have returned or are newly diagnosed. The treatment combines a vaccine designed to train the immune system to attack the cancer with a drug (nivolumab) that helps th…

This study compares two established chemotherapy treatments for young children with a specific type of low-risk brain tumor called medulloblastoma. The main goal is to see which treatment better preserves children's long-term thinking skills, learning ability, and quality of life…

This early-stage study is testing a new type of personalized cell therapy called B7-H3 CAR T cells in children and young adults whose brain tumors have come back or gotten worse. The main goals are to find a safe dose and see if the body can successfully make the treatment. Parti…