Brain tumor trial aims to find kinder chemo for toddlers
NCT ID NCT07291102
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial compares two standard chemotherapy regimens for children under 5 with a low-risk type of medulloblastoma. The main goal is to see which approach better protects thinking and learning skills 2.5 years after diagnosis. The study will also track survival and side effects. About 96 children will take part across multiple hospitals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
chemotherapy (carboplatin, etoposide, cisplatin, vincristine, cyclophosphamide, methotrexate, thiotepa)
What this could lead to
If successful, this trial could identify which standard chemotherapy regimen better preserves thinking and learning abilities in young children with medulloblastoma.
What could go wrong
This is an early-stage comparison of existing treatments, not a new therapy. The study is small (96 participants) and results may not apply to all patients. Chemotherapy carries risks like infection, organ damage, and long-term side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's of Alabama
Birmingham, Alabama, 35233, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••