Brain tumor trial aims to find kinder chemo for toddlers
NCT ID NCT07291102
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial compares two standard chemotherapy regimens for children under 5 with a low-risk type of medulloblastoma. The main goal is to see which approach better protects thinking and learning skills 2.5 years after diagnosis. The study will also track survival and side effects. About 96 children will take part across multiple hospitals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chemotherapy (carboplatin, etoposide, cisplatin, vincristine, cyclophosphamide, methotrexate, thiotepa)
- What this could lead to
- If successful, this trial could identify which standard chemotherapy regimen better preserves thinking and learning abilities in young children with medulloblastoma.
- What could go wrong
- This is an early-stage comparison of existing treatments, not a new therapy. The study is small (96 participants) and results may not apply to all patients. Chemotherapy carries risks like infection, organ damage, and long-term side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's of Alabama
Birmingham, Alabama, 35233, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Other studies related to the condition(s) this trial covers.
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