Could a vaccine train Kids' bodies to fight brain cancer?
NCT ID NCT04978727
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tests a vaccine called SurVaxM in 35 children with certain brain tumors that have come back or are hard to treat. The vaccine is designed to teach the immune system to find and destroy tumor cells that have a protein called survivin. The goal is to see if it is safe and whether it can help control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SurVaxM vaccine (with Montanide ISA 51 and sargramostim)
- What this could lead to
- If it works, this could point toward a new treatment option for children with certain recurrent brain tumors by training the immune system to attack cancer cells.
- What could go wrong
- This is a very early, small pilot study (Phase 1) with only 35 participants, so results may not apply broadly. The vaccine may cause side effects or fail to control tumor growth.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann and Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90026, United States
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Children's National
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Lucile Packard Children's Hospital at Stanford University Medical Center
Palo Alto, California, 94304, United States
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Memorial Sloan Kettering
New York, New York, 10065, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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University of Florida
Gainesville, Florida, 32608, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can trained immune cells outsmart brain tumors?
- Can the Body's own immune cells beat a recurrent brain tumor?
- Could a parasite drug fight childhood brain tumors?
- Can AI read tumor slides to outsmart childhood cancer?
- Could an antiparasitic drug boost radiation against childhood brain tumors?
- Can mapping the Blood-Brain barrier in brain tumors unlock new clues?