GLIOBLASTOMA MULTIFORME

This study tests a new approach for people with a recently diagnosed aggressive brain cancer called glioblastoma. A device with 9 ultrasound emitters is implanted in the skull to temporarily open the blood-brain barrier, allowing immune-boosting drugs to reach the tumor more effe…

This early-phase study tests a new treatment for people with recurrent high-grade brain tumors (astrocytomas). A specially designed virus carrying two 'suicide' genes is injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the sa…

This study tests a new gene therapy (HSV-tk) plus valacyclovir, along with radiation and chemotherapy, in people with recurrent glioblastoma, an aggressive brain cancer. The goal is to see if this combination can help patients live longer. About 62 adults whose cancer has returne…

This study tests whether giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and works for children and young adults under 22 whose brain tumors have come back or not responded to treatment. About 20 participants will rec…

This study tests whether a strict ketogenic diet, compared to standard dietary advice, can improve survival in 170 adults newly diagnosed with glioblastoma, a serious brain cancer. All participants continue standard treatments like chemotherapy and radiation. The diet lasts 18 we…

This study tests two drug combinations given after radiation for children and young adults with aggressive brain tumors (high-grade glioma or DIPG). One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these combinations …

This study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other …

This study tests a drug called NEO100 (perillyl alcohol) in about 49 people with a specific type of aggressive brain cancer (grade III or IV glioma) that has an IDH1 mutation and has returned or worsened. The goal is to find the safest dose and see if it helps people live longer.…

This study is for people aged 65 and older with a newly diagnosed aggressive brain cancer called glioblastoma who are too frail for standard long treatments. It compares chemotherapy alone to chemotherapy plus radiation to see if the chemo-only approach works just as well with fe…

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, a serious brain cancer. About 32 adults whose tumor has come back after prior treatment will be randomly assigned to get Avastin alone or Avastin…

This study tests a new treatment for people with aggressive brain tumors like glioblastoma. It combines a genetically modified virus (M032) that attacks tumor cells and boosts the immune system, with the immunotherapy drug pembrolizumab. The goal is to see if this combination is …

This early-phase study tests the safety of a new treatment for glioblastoma, an aggressive brain cancer that has returned or not responded to standard therapy. The treatment involves taking a patient's own immune cells (T cells), modifying them in a lab to recognize and attack ca…

This study tests a new approach for people with a severe brain cancer called glioblastoma. Researchers take a patient's own blood stem cells, add a protective gene, and return them so the bone marrow can withstand higher doses of chemotherapy. The goal is to safely give stronger …

This early-stage trial tests whether adding an immunotherapy drug (retifanlimab) to standard treatment (carmustine wafers, radiation, and possibly temozolomide) is safe and helps people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 50 adults who have alrea…

This study tests a new approach for people newly diagnosed with glioblastoma, an aggressive brain cancer. Participants receive a short course of targeted radiation plus an immunotherapy drug (atezolizumab) before surgery to remove the tumor. The goal is to see if this combination…

This early-stage study tests whether using sound waves (NaviFUS system) can help the drug bevacizumab work better for people with recurrent glioblastoma, an aggressive brain cancer. About 10 adults whose cancer has returned after standard treatments will receive the drug plus sou…

This study tests whether combining an immunotherapy drug (pembrolizumab) with targeted radiation before surgery is safe and can help people with recurrent glioblastoma, a severe brain cancer. About 10 adults whose tumor has returned after prior treatment will receive this combina…

This early-phase study tests a radioactive drug (131I-TLX101) given alongside standard care for people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal is to find a safe dose and check for side effects. About 12 adults who have had surgery for glioblas…

This study tests whether adding a drug called tarlatamab to standard radiation therapy is safe and effective for cancers that have a protein called DLL3, such as certain lung cancers, melanomas, and bladder cancers. About 30 adults with advanced or returning cancers will receive …

This early-stage study is testing whether a device called TheraSphere GBM is safe for people whose glioblastoma brain tumor has come back. About 36 adults with recurrent glioblastoma will receive the treatment. The main goal is to check for serious side effects and see if the pro…

This early-stage trial tests a specially engineered virus, G207, in children and young adults whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is given to help t…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This study is testing whether adding a new experimental medicine called APG-157, taken as dissolving pastilles in the mouth, can improve outcomes for people whose high-grade glioma (a type of aggressive brain tumor) has returned after previous treatment. Participants will take th…

This study tests sonobiopsy, a noninvasive technique that uses focused ultrasound to release tumor DNA into the bloodstream for easier detection. About 40 adults with suspected glioblastoma will undergo the procedure before standard surgery. The goal is to see if this method can …

This study collects samples of glioblastoma (a type of brain tumor) and blood from 120 adults during standard surgery. Researchers will examine tissue from different parts of the same tumor to see how they differ. The goal is to learn more about the tumor's structure and behavior…

This study is testing a new combined MRI and PET scan to measure how brain tumors use energy. Researchers will compare scan results with tissue samples from 50 adults with glioblastoma who need surgery. The goal is to improve imaging, not to treat the disease directly.

This study is for children, teens, and young adults (ages 1 to 39) newly diagnosed with a high-grade glioma, a serious type of brain tumor. Researchers will analyze the tumor's genetic makeup to see if it matches a specific treatment plan in a future study. The goal is to learn m…

This study is collecting blood and urine samples from 200 adults with glioblastoma (a serious brain tumor) who are receiving radiation therapy. Researchers want to see if levels of two proteins, VEGF and MMP, can help predict whether the tumor will come back within one year. The …