GLIOBLASTOMA MULTIFORME

This study is testing whether adding an immunotherapy drug called retifanlimab to standard glioblastoma treatment improves outcomes. The trial will enroll 50 adults newly diagnosed with this aggressive brain cancer to evaluate safety and survival. Researchers want to see if combi…

This early-stage study is testing a new combination treatment for adults with aggressive brain cancer that has returned after prior therapy. After surgeons remove as much tumor as possible, a modified virus is injected into the area to target remaining cancer cells. The main goal…

This small, early-stage study is testing a new approach for treating glioblastoma, an aggressive brain cancer. Researchers want to see if giving a short course of targeted radiation along with an immunotherapy drug (atezolizumab) *before* surgery can help the patient's own immune…

This study is testing whether chemotherapy alone works as well as the standard combination of chemotherapy plus radiation for elderly and frail patients with newly diagnosed glioblastoma, an aggressive brain cancer. Researchers want to see if skipping radiation reduces side effec…

This study is testing a two-part treatment for people whose aggressive brain cancer (glioblastoma) has come back. It combines a drug that helps the immune system fight cancer with a very precise form of radiation, given before planned surgery. The main goals are to see if this co…

This study is testing whether adding the drug ruxolitinib to the standard treatment (radiation plus temozolomide) works better for people newly diagnosed with glioblastoma, a serious type of brain cancer. About 190 adults will be randomly assigned to receive either the standard t…

This study is testing whether it is safe to combine a new targeted drug called tarlatamab with standard radiation therapy. It is for adults with advanced cancers that have a specific protein called DLL3, including certain lung cancers, melanoma, and others. The main goal is to se…

This study is testing whether adding a new experimental medicine called APG-157, taken as dissolving pastilles in the mouth, can help control aggressive brain tumors (high-grade glioma) that have returned after previous treatment. The APG-157 pastilles are given alongside the sta…

This study is testing the safety of an experimental virus therapy called G207 for children and young adults with recurrent or hard-to-treat brain tumors in the cerebellum. The virus is designed to infect and kill cancer cells while sparing healthy ones. Researchers will also test…

This early-stage study is testing the safety of a radioactive drug called 131I-TLX101 when added to standard treatment for newly diagnosed glioblastoma, an aggressive brain cancer. Researchers will give increasing doses to 12 patients who have recently had surgery but haven't sta…

This study aims to find better treatments for children and young adults newly diagnosed with aggressive brain tumors. Researchers will analyze the genetic makeup of each patient's tumor to match them with a targeted therapy that might work best for their specific cancer. The goal…

This study is testing a targeted drug called lorlatinib in children and young adults (ages 1-21) newly diagnosed with aggressive brain tumors (high-grade gliomas) that have specific genetic changes called ALK or ROS1 fusions. The main goals are to see if the drug can control the …

This study is testing two different drug combinations to see if they can help children and young adults with aggressive brain tumors live longer. The trial is for patients who have just finished radiation therapy. One group receives two drugs (ribociclib and everolimus), while an…

This study is testing a new approach for treating glioblastoma, a very aggressive brain cancer. Researchers are implanting a small ultrasound device in the brain to temporarily open the protective blood-brain barrier. The goal is to allow powerful immune-boosting drugs to better …

This trial is testing a new approach for treating a fast-growing brain cancer called glioblastoma. Doctors first collect a patient's own blood stem cells and modify them with a protective gene in the lab. These modified cells are then given back to the patient to help their bone …

This early study is testing a new device called TheraSphere GBM that delivers targeted radiation directly to recurrent glioblastoma brain tumors. The research aims to see if this approach is safe and technically possible for patients whose cancer has returned after standard treat…

This study is testing whether following a strict ketogenic diet (high-fat, very low-carb) alongside standard cancer treatment helps people with newly diagnosed glioblastoma live longer. Researchers will compare the keto diet to standard dietary advice in 170 patients over 18 week…

This study is testing a new combination treatment for aggressive brain cancers like glioblastoma. It combines a genetically engineered virus designed to attack cancer cells with an immunotherapy drug that helps the immune system fight the tumor. The trial aims to find a safe and …

This study is testing the safety of a new type of personalized immune cell therapy for adults with glioblastoma that has returned or stopped responding to standard treatments. Doctors collect a patient's own immune cells, engineer them in a lab to target a specific protein on the…

This study is testing a new way to deliver cancer drugs directly to the brain for children and young adults whose brain tumors have come back or haven't responded to standard treatments. Doctors use a tiny catheter to deliver two existing drugs (cetuximab and bevacizumab) precise…

This study is testing the safety and early effectiveness of an experimental nasal spray called NEO100 for adults with aggressive brain tumors (Grade III or IV gliomas) that have grown back after standard treatment. The spray aims to deliver treatment directly to the brain to try …

This study is testing a new noninvasive method called 'sonobiopsy' that uses focused ultrasound to help detect genetic markers from brain tumors in blood samples. Researchers want to see if this approach can provide detailed information about glioblastoma tumors without requiring…

This study aims to find out if measuring certain proteins in the blood and urine of patients with a serious brain tumor (glioblastoma) can help predict if the cancer will come back within a year after radiation treatment. Researchers will collect samples from about 200 adults bef…

This study is testing a new type of combined MRI and PET scan to see if it can accurately measure how brain tumor cells use energy (a process called glycolysis). Researchers will compare scan results from 50 adults with glioblastoma to actual tissue samples taken during their pla…

This study aims to better understand glioblastoma, an aggressive brain cancer, by collecting and preserving tumor tissue during standard surgery. Researchers will take samples from different parts of the same tumor to study how they differ in structure and genetics. The goal is t…