New combo attack on recurrent brain tumors shows promise in early trial
NCT ID NCT02800486
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a new way to deliver the cancer drug cetuximab directly into the brain's arteries, along with mannitol to open the blood-brain barrier, plus targeted radiation. It is for adults with recurrent glioblastoma or other aggressive brain tumors that have high levels of a protein called EGFR. The goal is to see if this combination can stop tumor growth and improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cetuximab (Erbitux) and mannitol, given directly into the brain's arteries, plus targeted radiation
- What this could lead to
- If it works, this could offer a new treatment option for people with recurrent brain cancers that have come back after standard therapy.
- What could go wrong
- This is a small, early-phase trial with only 37 participants, so results may not apply to everyone. The treatment involves direct infusion into brain arteries and radiation, which carry risks like brain swelling or damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Lenox Hill Brain Tumor Center
RECRUITINGNew York, New York, 10075, United States
Contact
Contact
Contact
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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