BRAIN TUMOR

This early-stage study is testing a new combination treatment for adults with aggressive brain cancer that has returned after prior therapy. After surgeons remove as much tumor as possible, a modified virus is injected into the area to target remaining cancer cells. The main goal…

This study is testing whether using focused ultrasound to temporarily open the protective blood-brain barrier can help standard immunotherapy drugs better reach and treat lung cancer that has spread to the brain. It will compare this new approach to standard treatment alone in ab…

This study is testing a new oral drug called TNG456, both alone and combined with another cancer drug (abemaciclib), in people with advanced solid tumors that have a specific genetic change called MTAP loss. The main goals are to find safe doses and see if the treatment can shrin…

This trial is testing if adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy (temozolomide) helps people with a specific type of recurrent brain tumor (glioblastoma) live longer. About 120 participants will be randomly assigned to receive either the real can…

This study is testing if a drug called tranexamic acid (TXA) can safely reduce dangerous bleeding during surgery to remove brain tumors. Researchers will compare TXA against a placebo in 102 adults undergoing this operation to see if it lowers blood loss and prevents serious comp…

This study is testing an oral drug called zotiraciclib for people whose aggressive brain tumors (gliomas) have come back after prior treatment. It is specifically for patients whose tumors have certain genetic changes (IDH1 or IDH2 mutations). The main goals are to find a safe do…

This study is collecting real-world information on a treatment called GammaTile, which involves placing small, dissolvable radiation tiles in the brain during surgery to target any remaining tumor cells. It will follow 600 patients for up to five years to see how well it controls…

This study is testing a new approach for treating a rare and aggressive brain tumor in children called DIPG. Researchers are using focused ultrasound waves to temporarily open the brain's protective barrier, aiming to help a chemotherapy drug (doxorubicin) reach the tumor more ef…

This study is testing if a drug called niraparib helps adults with a newly diagnosed, aggressive brain tumor (glioblastoma) live longer than the current standard drug, temozolomide. About 450 participants will be randomly assigned to receive one of these two drugs, taken daily al…

This study is testing proton radiation therapy for adults with benign or slow-growing brain tumors. The main goal is to see how well the treatment controls tumor growth over five years. Researchers will also closely track the patient's quality of life and any side effects from th…

This early study is testing whether the drug troriluzole can help control recurrent glioblastoma, an aggressive brain cancer. About 27 adults whose cancer has returned will receive the drug either before and after standard tumor-removal surgery, or only after surgery, to see if i…

This study is testing a two-step treatment for brain tumors (gliomas) that have come back. First, doctors use a laser to heat and destroy tumor tissue. Then, patients receive a short, intense course of radiation therapy. The goal is to see if this combination can control the tumo…

This study is testing whether a special type of MRI scan can accurately tell the difference between a brain tumor growing back versus harmless swelling caused by previous radiation treatment. Researchers are enrolling 101 adults with brain metastases who need surgery to remove a …

This study is testing a new imaging agent called panitumumab-IRDye800 to see if it is safe and can help surgeons better see brain tumors during surgery in children and young adults. The dye is designed to make tumor cells glow under special lights, potentially helping surgeons re…

This study is testing new brain scan software designed to help surgeons better plan brain tumor removal. The software creates detailed maps of critical brain areas for language and movement to help avoid damaging them during surgery. Researchers will compare the new software's ac…

This study is testing an improved version of a special PET scan called 18F-DOPA. The goal is to see if using a newer scanner and a common medication (furosemide) can make the images clearer, especially in the lower abdomen. This could help doctors better detect and plan treatment…

This study is testing a new, faster type of MRI scan to help doctors tell the difference between a brain tumor that has come back and damage caused by previous radiation treatment. Currently, this often requires risky brain surgery to confirm. The research involves 60 people, inc…

This study is testing whether brain training exercises delivered through virtual reality (VR) headsets are practical and acceptable for children and young adults (ages 8-22) who are receiving radiation treatment for brain tumors. Researchers want to see if this fun, immersive app…

This study is testing a home-based program called HOBSCOTCH-CA, designed to help brain cancer survivors manage memory and thinking problems that often follow their illness. Participants will work one-on-one with a coach over video calls to learn problem-solving and relaxation tec…

This study is testing whether wearing special light glasses for 30 minutes each weekday can help reduce fatigue and improve attention and thinking skills in children and teens who have survived a brain tumor. It's a small pilot study with 40 participants to see if this approach i…

This study is testing whether brain tumor patients can safely receive radiation therapy without the standard, uncomfortable plastic mask. It uses a camera system to track a patient's position in real-time instead. The goal is to see if this mask-free approach works technically an…

This study is testing the safety and practicality of placing a small, permanent device called an Ommaya reservoir during brain tumor surgery. The device, placed under the scalp, allows doctors to easily collect spinal fluid multiple times after surgery. The goal is to use these r…

This study is building a large database of information from people with brain tumors. It will collect brain scans, treatment details, and health outcomes from up to 70,000 participants. The goal is to use this data to create better tools for predicting how tumors behave and how p…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study aims to build a collection of biological samples from adults diagnosed with brain tumors. The goal is to create a resource for future research to better understand these diseases. Participants will provide samples but will not receive any experimental treatment as part…

This study is testing a new type of ultra-thin, flexible brain mapping electrode made from graphene material during brain tumor surgery. Researchers want to see if these new electrodes are safe to use and if they can record clearer brain signals than current devices. Ten patients…

This study aims to understand if the community of bacteria in a child's gut is connected to brain tumors. Researchers will analyze stool samples from 100 children aged 3-18 who are suspected of having a brain tumor and are scheduled for surgery. The goal is to see if changes in g…

This study aims to learn more about glioblastoma, a serious brain tumor, by observing 100 newly diagnosed adults. Researchers will measure specific proteins in the blood and tumor tissue to see how they relate to MRI brain scan features and change during standard treatment. The g…

This study aims to better understand how patients recover from brain or spine surgery and how complications affect their well-being. Researchers will use a smartphone app to collect daily reports from 400 patients about how they feel before and after their operation. The goal is …

This study aims to find signs in the blood that show if brain cancer treatments are causing injury to a child's brain. Researchers will follow 560 children with brain tumors and healthy kids, taking blood samples over three years to compare those who get radiation, chemotherapy, …

This study aims to create 3D models called 'immune organoids' from children's own cells to better understand how pediatric cancers interact with the immune system. Researchers will use tissue samples from up to 108 patients aged 25 or younger with brain tumors, kidney tumors, neu…

This study aims to understand how focused ultrasound affects the area around brain tumors during surgery. Researchers will use ultrasound on parts of the tumor and nearby brain tissue, then place tiny catheters to collect fluid samples. The goal is to learn how ultrasound changes…