BRAIN TUMOR

This study tests a new oral drug, TNG456, in people with advanced solid tumors that have lost a gene called MTAP. The drug works by blocking a protein (PRMT5) that these tumors need to grow. The study has two parts: first, finding the safest dose of TNG456 alone or with abemacicl…

This study tests if a drug called tranexamic acid (TXA) can reduce blood loss during surgery to remove brain tumors. About 102 adults having a craniotomy will receive either TXA or a placebo during the operation. Researchers will compare blood loss and complications between the t…

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor (glioblastoma) live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned to r…

This early-phase study tests a new treatment for people with recurrent high-grade brain tumors (astrocytomas). A specially designed virus carrying two 'suicide' genes is injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the sa…

This study tests a new way to deliver a cancer drug directly to the brain along with repeat radiation for people whose aggressive brain tumors have come back. The drug, cetuximab, targets a protein common on these cancer cells. The goal is to see if this combination can stop tumo…

This study tests a two-step treatment for people with newly diagnosed high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to kill remaining cancer cells. The goal is to control…

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, a serious brain cancer. About 32 adults whose tumor has come back after prior treatment will be randomly assigned to get Avastin alone or Avastin…

This study tests a device that uses focused ultrasound to temporarily open the blood-brain barrier in people with brain metastases from non-small cell lung cancer. The goal is to see if this helps standard immunotherapy drugs work better against the brain tumors. About 30 adults …

This study tests whether sitagliptin, a diabetes drug, can help the immune system fight glioblastoma, an aggressive brain tumor. About 48 adults with progressive grade 4 glioma will receive sitagliptin before surgery to see if it increases cancer-fighting immune cells in the tumo…

This study is testing proton radiation therapy in 100 adults with benign or slow-growing brain tumors. The goal is to see how well it controls tumor growth and how it affects quality of life and side effects. Participants receive targeted proton beams to the tumor area and are fo…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard therapy. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to control the tumor and see if the combination is s…

This early-stage study tests whether using sound waves (NaviFUS system) can help the drug bevacizumab work better for people with recurrent glioblastoma, an aggressive brain cancer. About 10 adults whose cancer has returned after standard treatments will receive the drug plus sou…

This study tests an experimental drug called zotiraciclib for people whose brain tumors (a type of glioma with IDH1 or IDH2 mutations) have returned after previous treatment. About 96 participants aged 15 and older will take the drug by mouth on a specific schedule over 28-day cy…

This study tests a new drug, niraparib, against the standard treatment temozolomide in adults with a newly diagnosed, hard-to-treat type of glioblastoma (a brain cancer). About 450 participants will be randomly assigned to one of the two drugs, taken daily during radiation. The m…

This study tests a special MRI method called Treatment Response Assessment Maps (TRAMs) to tell whether an enlarged spot in the brain after radiation is a returning tumor or harmless scar tissue. About 101 adults with brain metastases who had focused radiation will get this MRI b…

This study is testing whether a dye called panitumumab-IRDye800 is safe and can help surgeons see brain tumors more clearly during surgery in children and young adults aged 6 months to 25 years. The dye makes tumor tissue glow, which may help surgeons remove more of the tumor whi…

This study is testing a special PET scan (18F-DOPA) to see if it can better detect and measure several conditions, including congenital hyperinsulinism in children, neuroblastoma, neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. About 800 children…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study tests whether daily bright light exposure can reduce fatigue and improve thinking in children and teens who have survived a brain tumor. About 40 participants will use a special light box at home for 6 weeks. The goal is to see if this approach is practical and liked b…

This study compares two virtual programs for adults with brain tumors who have trouble with thinking or memory. One program combines cognitive rehab with mindfulness training; the other offers educational videos on brain health. Participants attend 8 weekly sessions, complete sur…

This study explores whether virtual reality (VR) can make cognitive training more engaging and effective for children aged 8-22 who are receiving radiation for brain tumors. About 45 participants will be randomly assigned to do brain exercises on an iPad or in a VR headset. Resea…

This study explores whether brain tumor patients can safely receive radiotherapy without wearing an immobilization mask. Instead, a surface imaging system will track their position and movement. Twenty adults will have one session with a mask and one without, comparing stability …

This study is tracking 600 people with different types of brain tumors who receive GammaTile radiation therapy during surgery. The goal is to see how well the treatment works and how safe it is in everyday medical practice. Researchers will measure how long tumors stay away and h…

This early-phase study tests whether letrozole, a drug used for breast cancer, can get into brain tumors and work with standard treatments. About 39 adults with recurrent high-grade gliomas will take letrozole before surgery to measure drug levels in tumor tissue. The goal is to …

This study aims to find blood markers that show if a child's brain has been injured by cancer treatment. Researchers will collect blood samples from 560 children with brain tumors before and after surgery, radiation, or chemotherapy, and compare them to samples from healthy child…

This study aims to create immune organoids—tiny, lab-grown models of the immune system—from the cells of children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will use these organoids to study how tumors interact with immune cells. The…

This study looks at how metabolism and the immune system might be connected to brain development in children with autism, epilepsy, brain tumors, or other psychiatric conditions. Researchers will collect blood samples and do behavioral assessments from up to 500 children to find …

This study looks at how focused ultrasound affects the fluid around brain tumors during surgery. Six adults with large brain tumors will have small catheters placed to collect samples from areas with and without ultrasound. The goal is to learn how ultrasound changes the tumor en…

This study looks at whether placing a small device called an Ommaya reservoir in the brain during tumor surgery is safe and works well. The reservoir lets doctors collect fluid from around the brain over time to study tumor markers. About 100 adults with brain tumors will take pa…

This study is testing whether a smartphone app can help track how patients feel after neurosurgery for conditions like disc disease, spine instability, brain tumors, or aneurysms. About 400 adults will use the app to report their well-being and any side effects before and for one…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with brain conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based tests with standard in-p…

This study aims to better understand how electrical stimulation of the brain during awake surgery affects hand strength and movement. Researchers will test different stimulation settings in 20 adults with brain tumors to find which ones help or hinder hand function. The goal is t…

This study looks at gut bacteria in children aged 3 to 18 who are suspected of having a brain tumor. Researchers will analyze stool samples to see if changes in bacteria can help detect the tumor or track its progress. No treatment is given—the goal is simply to learn more about …

This study is testing a new software that uses fMRI scans to create detailed maps of important brain areas, like those controlling movement and language, before brain tumor surgery. The goal is to help surgeons avoid damaging these critical regions during tumor removal. The study…

This early study tests a new graphene-based electrode for brain mapping during surgery to remove brain tumors. Ten adults with glioma will have the device used alongside standard monitoring to check its safety and how well it records brain signals. Some participants who are awake…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study aims to collect and store biological samples (like tumor tissue or blood) from 500 adults with confirmed brain tumors. The samples will be used for future research to better understand brain tumors. No treatment or experimental therapy is given—this is purely a sample …

This study is creating a huge database of brain tumor patients (70,000 people) to help doctors better understand and treat these cancers. Researchers will collect MRI scans, lab results, and health outcomes from people with gliomas and other brain tumors. The goal is to use this …

This study tests the drug troriluzole in people with recurrent glioblastoma, a type of brain cancer. Participants take the drug before surgery to see how it affects brain activity and glutamate levels in the tumor. The goal is to learn more about the drug's effects, not to treat …

This study tests a new MRI technique to measure a chemical called 2HG in brain tumors (gliomas) without needing surgery. Researchers will compare MRI results with tissue samples from 30 adults who are already scheduled for tumor removal. The goal is to improve how doctors track a…

This study tests a faster, more detailed MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can tell the difference between a brain tumor coming back and radiation-induced brain damage. About 60 adults who have had brain radiation, have new or untreated bra…

This study aims to understand the role of two specific proteins (MMP2 and MMP9) in glioblastoma, a very aggressive brain tumor. Researchers will track 100 newly diagnosed patients to see how levels of these proteins in the blood change before and after surgery and standard treatm…