New imaging trial aims to sharpen diagnosis for Parkinson's, tumors, and more

NCT ID NCT04706910

Recruiting now Diagnosis Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study is testing an improved PET/CT imaging method using a radioactive tracer called 18F-DOPA. Researchers want to see if it can better detect small lesions and reduce image artifacts in patients with conditions like congenital hyperinsulinism, neuroblastoma, neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. About 800 participants will receive an injection of the tracer, and some will also get a diuretic to improve image quality.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 18F-DOPA (a radioactive tracer) and furosemide (a diuretic) for some participants
What this could lead to: If successful, this could lead to clearer, more accurate PET scans for diagnosing and monitoring several serious diseases.
What could go wrong: This is an imaging optimization study, not a treatment trial. It may not directly improve patient outcomes, and results may not apply to all imaging centers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BRAIN TUMOR are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm Congenital Hyperinsulinism familial hyperinsulinism Lewy body dementia Lewy Body Disease neuroblastoma neuroendocrine neoplasm Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR CONGENITAL HYPERINSULINISM LEWY BODY DISEASE NEUROBLASTOMA NEUROENDOCRINE TUMORS PARKINSON DISEASE

Contacts and locations

Locations

WC Mackenzie Health Science Centre / University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.