Can a targeted drug reach brain tumors? small trial aims to find out

NCT ID NCT06807619

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing whether the drug sotorasib can get into KRAS G12C+ brain tumors and how safe and effective it is. Sixteen adults with these tumors who are already scheduled for brain surgery will receive the drug. Researchers will measure how much drug reaches the tumor and track tumor response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sotorasib (AMG 510)
What this could lead to: If successful, this could show that sotorasib effectively targets KRAS G12C+ brain tumors, potentially leading to a new treatment option for this specific type of metastatic brain cancer.
What could go wrong: This is a very early Phase 1 trial with only 16 participants, so results may not apply broadly. The drug may not penetrate brain tumors well or could cause side effects, and it is not designed to cure the disease.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR

Contacts and locations

Locations

Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering West Harrison (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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