BRAIN TUMOR

This early-phase study tests a modified virus designed to attack brain tumor cells that have come back or grown despite previous treatment. About 62 adults with certain types of brain cancer will receive the virus directly into the tumor, sometimes with a drug to boost the immune…

This study tests a higher dose of a precise type of radiation called proton therapy for people with aggressive meningiomas (brain tumors). The goal is to find a safe dose that can better control the tumor after surgery. The trial includes 21 adults with either grade II or grade I…

This early-stage study tests whether focused ultrasound can safely open the blood-brain barrier in children with a rare, aggressive brain tumor called DIPG. The goal is to let the chemotherapy drug doxorubicin reach the tumor more effectively. Ten children aged 5 to 18 who have c…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at higher risk of coming back after radiation alone. About 134 adults with cancers like melanoma, lung, breast, or colorectal cance…

This study tests whether focused ultrasound can safely open the blood-brain barrier in children with DIPG, a hard-to-treat brain tumor. The goal is to let the chemotherapy drug doxorubicin reach the tumor more effectively. Ten children ages 5 to 21 will be treated, and researcher…

This study follows 160 people of any age who have or will get a CODMAN CERTAS Plus valve to manage hydrocephalus (fluid buildup in the brain). The main goal is to see if the valve is placed correctly and works as intended 30 days after surgery, without needing extra procedures. T…

This study tests a new MRI technique called magnetic resonance fingerprinting (MRF) to see if it can improve how doctors diagnose and assess brain tumors. About 172 people with brain tumors will get an MRF scan, and the results will be compared with standard tests and biopsy resu…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can be used at home to boost recovery of memory, language, and thinking skills in people with stroke, brain tumors, or neurodegenerative conditions like Parkinson's or Alzheimer's. Participants …

This study tests a new way to deliver proton radiation to children with brain tumors that require radiation to the brain and spine. The approach spares parts of the backbone to reduce side effects like low blood counts and slowed growth. About 20 children aged 3 to 18 will receiv…

This study looks at how the brain processes spoken language by recording brain activity in people with epilepsy or brain tumors who already have electrodes placed for medical reasons. Researchers will compare brain signals from English, Spanish, and Mandarin speakers to uncover u…

This study tests whether adding a breath-holding task to standard functional MRI (fMRI) can better identify essential brain areas in people with brain tumors. Researchers will compare standard brain mapping with a version that uses breath-holding data to see if it reduces false r…

This study uses special PET and MRI scans to measure oxygen levels, blood flow, and metabolism in brain and cervical tumors. About 20 adults with high-grade glioma or cervical cancer will undergo these scans before starting their standard treatment. The goal is to learn how tumor…

This study watches 66 adults with brain tumors to see how tumors in the cerebellum (the brain's balance center) affect thinking, memory, and movement. Researchers compare patients with cerebellar tumors to those with tumors elsewhere in the brain. The goal is to learn which tumor…

This study looks at how two different anesthetic drugs, fentanyl and ketamine, affect brain wave readings during surgery in children aged 2-18 who have epilepsy and a brain tumor. The goal is to see which drug helps surgeons better detect seizure-related brain activity. The trial…

This study uses a special PET scan to measure brain inflammation caused by radiation therapy in children with medulloblastoma. About 22 participants will be scanned before, during, and up to two years after treatment. The goal is to understand how radiation affects different brai…

This study looks at how proton beam radiation affects brain connections and thinking skills in children and young adults (ages 6-25) treated for brain tumors. Researchers use special MRI scans taken at rest, along with thinking tests and quality-of-life questionnaires. Both patie…

This study looks at whether adding a weekly check by a specially trained medical technician (called a MERM) to the usual doctor visits can improve how we spot side effects in people getting proton therapy for brain or head-and-neck tumors. About 92 adults will be randomly assigne…

This study follows over 1,500 young adult survivors of childhood cancers like leukemia, brain tumors, and Hodgkin lymphoma to see how frailty—a measure of physical weakness and vulnerability—changes over five years. Researchers want to find out if frailty can predict future chron…

This study looks at how surviving a pediatric brain tumor affects children's thinking, memory, and behavior. Researchers will track how many eligible survivors join the study to see if this type of research is possible. The goal is to better understand the long-term effects of ca…