BRAIN TUMOR

This study is testing a more precise form of radiation therapy (proton therapy) for children with brain tumors that require radiation to the brain and spine. The goal is to see if this method can protect the bones and bone marrow in the spine, aiming to reduce side effects like g…

This study follows 160 patients for three years after they receive a programmable brain shunt valve to treat fluid buildup in the brain (hydrocephalus). The goal is to monitor how well the device stays in place and functions over time. Data is collected during standard doctor vis…

This is a first-in-human safety study testing a genetically engineered virus, rQNestin34.5v.2, as a potential treatment for recurrent malignant brain tumors (gliomas). The virus is designed to infect and kill only cancer cells while sparing healthy brain tissue. The main goals ar…

This study is testing whether a more focused, higher-dose form of proton radiation can better control aggressive brain tumors called meningiomas. It involves 21 adults with specific types of these tumors that have been partially or fully removed by surgery. The main goal is to fi…

This study is testing a new type of MRI scan called magnetic resonance fingerprinting (MRF) to see if it can improve how doctors diagnose and monitor brain tumors. Researchers will compare the detailed pictures from this new scan with standard scans, biopsy results, and patient o…

This study is testing whether adding a special breath-holding MRI scan to the standard pre-surgery brain mapping process makes it more accurate. Researchers want to see if this combined approach better identifies critical brain areas involved in speech and movement, which surgeon…

This Mayo Clinic study is testing whether a home-based brain stimulation device, combined with daily activities, can help people recover thinking and language skills after a stroke, brain tumor, or neurodegenerative disease. The research aims to see if this approach is practical …

This study is testing two different virtual programs designed to help brain tumor patients with memory, thinking, and overall brain health. Participants are randomly assigned to receive either C-SMART, which combines memory training with mindfulness meditation, or BE Well, which …

This study aims to understand how proton beam radiation therapy for brain tumors affects brain connections, thinking skills, and quality of life in children and young adults (ages 6-25). Researchers will use special brain scans and thinking tests to compare patients who received …

This study aims to learn more about how brain and cervical cancers work by using two types of advanced scans (PET and MRI) together. Researchers want to see how oxygen levels and blood flow inside these tumors relate to each other and to features seen under a microscope. The stud…

This study tests whether adding weekly check-ins with specially trained medical technicians helps doctors better identify and track treatment side effects in patients receiving proton therapy for brain tumors. The trial involves 92 adult patients and randomly assigns them to rece…

This study aims to understand how tumors in a specific part of the brain called the cerebellum affect a person's thinking skills and coordination before and after surgery. Researchers will compare 66 adults with tumors in the cerebellum to those with tumors in other brain areas. …

This study aims to determine which of two common anesthesia drugs (fentanyl or ketamine) works better for mapping brain activity during surgery for children with brain tumors and epilepsy. Doctors place electrodes directly on the brain during surgery to identify areas causing sei…

This study aims to improve how surgeons monitor hand function during awake brain tumor surgery. Researchers will test a special data glove and different stimulation settings to measure hand strength and movement more precisely. The goal is to help surgeons remove as much tumor as…

This study aims to understand how surviving a childhood brain tumor affects long-term thinking, memory, and behavior. Researchers are comparing brain scans and thinking tests from 42 survivors to those of healthy children. The goal is to identify biological reasons for any lastin…

This study aims to understand why many young adults who survived childhood cancer experience early signs of aging and frailty, which can lead to serious health problems later in life. Researchers will follow over 1,500 survivors for five years, measuring their physical fitness an…

This study aims to discover how the human brain understands speech across different languages like English, Spanish, and Mandarin. Researchers will record brain activity from patients already undergoing brain surgery for epilepsy or tumors. The goal is to map how speech sounds ar…

This study aims to understand how radiation therapy for brain tumors causes inflammation in the brain. Researchers will use special PET scans and optional MRI scans on 22 children with medulloblastoma to measure this inflammation over two years. The goal is to learn how this infl…