Virus therapy takes on brain cancer in early trial

NCT ID NCT03152318

First seen Mar 04, 2026 · Last updated Jun 15, 2026 · Updated 13 times

Summary

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. The virus is designed to attack tumor cells, and some participants also receive a drug called cyclophosphamide to help the immune system respond.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02215, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • Johns Hopkins University Medical Center

    Baltimore, Maryland, 21287, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

Conditions

Explore the condition pages connected to this study.