BRAIN CANCER

This early-phase study tests a new treatment for people with recurrent high-grade brain tumors (astrocytomas). A specially designed virus carrying two 'suicide' genes is injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the sa…

This study tests a new way to deliver a cancer drug directly to the brain along with repeat radiation for people whose aggressive brain tumors have come back. The drug, cetuximab, targets a protein common on these cancer cells. The goal is to see if this combination can stop tumo…

This study tests whether adding silevertinib (an oral targeted therapy) to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. About 162 adults whose tumors have certain genetic markers (…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study looks at how much of the drug T-DXd gets into brain tumors after being injected into the body. It includes 30 adults with brain cancer that has the HER2 protein. Researchers will measure drug levels in the tumor during surgery to see if it could be a useful treatment.

This study aims to better understand how electrical stimulation of the brain during awake surgery affects hand strength and movement. Researchers will test different stimulation settings in 20 adults with brain tumors to find which ones help or hinder hand function. The goal is t…

This study looks at whether a special PET scan using 18F-Fluciclovine can find leftover brain tumor that standard MRI might miss after surgery. About 20 adults who had brain metastasis removed and are scheduled for radiation will get an optional PET scan before radiation. The goa…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study tests whether advanced MRI scans can better predict which parts of a malignant glioma (brain tumor) are most likely to come back after treatment. Researchers will use these scans to design safer, more targeted radiation plans. About 135 adults with suspected or confirm…

This study tests a special version of the cancer drug nivolumab that has a fluorescent dye attached, called nivo800. The dye makes the drug glow, so doctors can see where it collects in brain tumors during surgery. The goal is to learn if this is safe and helps surgeons see tumor…

This study is testing a new technology called SmartMatch that checks how a person's brain tumor tissue reacts to different drugs. The goal is to see if the test can give results within 21 days after surgery. About 80 people aged 15 and older with recurrent brain tumors who are al…

This study looks at whether a special imaging agent called 18F-fluciclovine can help doctors see if radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT sca…