New hope for recurrent glioblastoma: experimental drug LMP744 enters human trials
NCT ID NCT07416188
First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 23 times
Summary
This study tests a new drug called LMP744 in people whose glioblastoma has come back after standard treatment. The drug is designed to kill cancer cells by blocking a key growth signal and interfering with DNA repair. Participants will receive the drug through a vein for 5 days each month, and will have surgery to remove tumor tissue for analysis. The goal is to see if the drug can shrink tumors and improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- LMP744 (a drug that targets cancer cell growth and DNA repair)
- What this could lead to
- If successful, this could provide a new treatment option for people with recurrent glioblastoma, potentially shrinking tumors and extending life.
- What could go wrong
- This is an early-phase trial with only 40 participants, so results may not apply to everyone. The drug may not work or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Email: •••••@•••••
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