Brain cancer radiotherapy gets a precision boost from advanced MRI

NCT ID NCT07512154

Recruiting now Disease control Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a special MRI scan, called amide proton transfer (APT) imaging, can help doctors target the most aggressive parts of brain tumors during radiotherapy. Twenty adults with glioblastoma or grade 4 astrocytoma will receive either standard radiotherapy or a new APT-guided approach. The goal is to see if the new method reduces tumor activity more effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiotherapy (APT-guided radiation)
What this could lead to: If successful, this could make radiotherapy for brain cancer more precise, potentially improving tumor control and reducing side effects.
What could go wrong: This is a small early-phase study with only 20 participants, so results may not apply widely. The new MRI technique may not improve outcomes over standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN CANCER

Contacts and locations

Locations

Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States

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