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New hope for glioblastoma? drug combo trial targets aggressive brain tumors

NCT ID NCT07326566

Recruiting now Disease control Sponsor: Black Diamond Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 11 times

Summary

This Phase 2 trial tests whether adding the experimental drug silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer worsening. The study includes 162 participants whose tumors have certain genetic markers (unmethylated MGMT and EGFRvIII). After surgery and radiation, some get the combo, others get chemotherapy alone, and researchers compare outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
silevertinib (an oral EGFR inhibitor) combined with temozolomide (chemotherapy)
What this could lead to
If it works, this could improve how long people with a hard-to-treat type of glioblastoma live without their cancer growing, compared to standard chemotherapy alone.
What could go wrong
This is a Phase 2 trial with only 162 participants, so results are still early. The combination may not work better than temozolomide alone, and side effects from the two drugs together could be more severe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer central nervous system disorder glioblastoma glioma glioma susceptibility 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN CANCER CENTRAL NERVOUS SYSTEM DISEASES GBM GLIOBLASTOMA (GBM) GLIOBLASTOMA MULTIFORME (GBM) GLIOMA NEWLY DIAGNOSED GLIOBLASTOMA

Contacts and locations

Locations

  • Atlantic Health

    RECRUITING

    Summit, New Jersey, 07901, United States

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact Email: •••••@•••••

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Henry Ford Cancer- Detroit

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Highlands Oncology Group

    RECRUITING

    Springdale, Arkansas, 72762, United States

  • Huntsman Cancer Institute, University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • John Theurer Cancer Center at Hackensack University Medical Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Johns Hopkins Sibley Memorial Hospital

    RECRUITING

    Washington D.C., District of Columbia, 20016, United States

  • Johns Hopkins Sidney Kimmel Cancer Center - Baltimore

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Miami Cancer Institute

    RECRUITING

    Miami, Florida, 33176, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • Montefiore Medical Center

    RECRUITING

    The Bronx, New York, 10461, United States

  • Northwell Health Center for Advanced Medicine - Brain Tumor Center

    RECRUITING

    Lake Success, New York, 11042, United States

    Contact Email: •••••@•••••

  • Prisma Health

    RECRUITING

    Greenville, South Carolina, 29605, United States

  • Rutgers Cancer Institute

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • Stanford University

    RECRUITING

    Palo Alto, California, 94304, United States

  • Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

    Contact Email: •••••@•••••

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Alabama at Birmingham O'Neal Comprehensive Cancer Center

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • Washington University School of Medicine Siteman Cancer Center

    RECRUITING

    St Louis, Missouri, 63108, United States

  • Yale Cancer Center

    RECRUITING

    New Haven, Connecticut, 06510, United States

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