Could a lifestyle makeover keep your brain sharp?
NCT ID NCT05007353
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to either the intensive program or a self-guided education group. The study aims to see if these lifestyle changes can protect memory and thinking over two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Structured Lifestyle Intervention (SLI) - a program combining physical exercise, healthy diet, cognitive training, social stimulation, and vascular risk management
- What this could lead to
- If successful, this could provide a practical, non-drug approach to delay cognitive decline and dementia in at-risk older adults.
- What could go wrong
- The trial is large but results depend on long-term adherence; lifestyle changes may be hard to sustain, and benefits might not be significant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Neuroscience Institute @ Tan Tock Seng Campus (NNI @ TTSH campus)
Singapore, Singapore, 308433, Singapore
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National University Hospital
Singapore, Singapore, 117600, Singapore
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National University of Singapore, Yong Loo Lin School of Medicine
Singapore, Singapore, 117600, Singapore
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