GLIOBLASTOMA (GBM)

This phase 2 trial tests whether adding DOC1021, a personalized dendritic cell vaccine, to standard treatment (surgery, chemo, radiation) improves survival in adults newly diagnosed with glioblastoma. About 180 participants will be randomly assigned to receive the vaccine plus st…

This Phase 2 trial tests whether adding the experimental drug silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer worsening. The study includes 162 participants whose tumors have c…

This early-phase trial tests a single dose of a radioactive drug called [177Lu]Lu-XT771 in people with recurrent glioblastoma, an aggressive brain cancer. The drug is injected directly into the cavity left after tumor removal surgery, aiming to deliver radiation precisely to canc…

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions: one helps a common drug kill cancer cells, and the other wakes up the immune system to attack…

This study is testing a combination of two drugs—a targeted radioactive drug (177Lu-DOTATATE) and a PARP inhibitor (olaparib)—in children and teens aged 3 to 18 with certain solid tumors that have come back or not responded to treatment. The goal is to see if the combination is s…

This study tests a minimally invasive laser treatment for glioblastoma that regrows shortly after initial surgery, before standard radiotherapy and chemotherapy begin. The goal is to see if the laser can safely treat the regrowth without delaying the planned follow-up treatments.…

This trial tests an experimental drug, BGB-58067, in people with a newly diagnosed and aggressive brain cancer called glioblastoma. The drug is designed to work specifically in tumors missing a certain gene (MTAP). The study first checks if the drug reaches the brain and affects …

This phase 2 pilot study tests whether granulocyte colony stimulating factor (G-CSF), a drug that boosts white blood cells, can help preserve brain structure and thinking skills in people with a specific type of glioblastoma (MGMT-methylated) undergoing standard chemoradiation. A…

This early-stage trial tests a new treatment for a fast-growing brain cancer called glioblastoma. It combines special immune cells (EGFR BATs) with low-intensity focused ultrasound to temporarily open the blood-brain barrier, allowing more treatment to reach the tumor. The study …

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with aggressive brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal…

This study tests a new drug, TLX101-Tx, that delivers radiation directly to glioblastoma cells. It is combined with standard chemotherapy (lomustine) and compared to chemotherapy alone in 50 adults whose brain cancer has returned after initial treatment. The goal is to see if the…

This study tests a new drug called MT-125 given together with standard radiation for people newly diagnosed with a fast-growing brain tumor called glioblastoma. The main goals are to find a safe dose and understand side effects. About 36 adults aged 18 and older with a specific t…

This phase 2 trial tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent glioblastoma from spreading to the brain and spinal cord lining. The study enrolls 38 newly diagnosed patients whose tumors touch brain fluid spaces or whose surgery …

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule. The therapy is given directly into the tumor area after standard treatments like surgery and chemotherapy. The goal is to see if it can …

This study tests a new way to deliver radiation therapy for glioblastoma, a fast-growing brain tumor. Instead of treating a large area, doctors use MRI-guided adaptive radiation to focus more precisely on the tumor with reduced margins. The goal is to see if this approach can bet…

This early-phase trial is testing an investigational drug called risvutatug rezetecan in 15 people with recurrent glioblastoma or brain metastases. The drug is designed to seek out and deliver a cancer-killing payload to tumor cells. The study first measures how much drug gets in…

This early-stage trial tests a new treatment called MSC11FCD for people with newly diagnosed glioblastoma, an aggressive brain cancer. The treatment uses donor stem cells that carry a 'suicide gene' and are injected into the brain during surgery to kill any remaining cancer cells…

This early-stage trial tests whether injecting an oncolytic virus directly into brain tumors can treat recurrent glioblastoma, a fast-growing cancer. Twenty participants will receive up to six injections over several weeks, with regular checkups to monitor safety and tumor respon…

This study tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can help people with glioblastoma that has invaded the brain's ventricles or lining. Participants will first have surgery to remove as much tumor as possible, then receive radiation, ora…

This phase 2 trial tests whether a higher daily dose of radiation over three weeks is better than the standard dose for people aged 65 and older with newly diagnosed glioblastoma, an aggressive brain cancer. About 56 participants will be randomly assigned to one of two radiation …

This study is testing a new AI-powered blood test that looks at platelets and immune cells to find early signs of eight different cancers, including lung, breast, and pancreatic cancer. Researchers will collect blood samples from 6,000 adults aged 40 and older, both with and with…

This study looks at whether virtual music therapy is practical and helpful for people recently diagnosed with glioblastoma, a serious brain cancer. Thirty-five participants will either join live music therapy sessions with a board-certified therapist or listen to curated playlist…

This pilot study looks at whether taking the chemotherapy drug temozolomide at a specific time of day (morning or evening) is practical for people with glioblastoma, a type of brain cancer. Fifty adults who have completed surgery and radiation will be randomly assigned to take th…

This study is testing a new virtual therapy program called FearLess, designed to help people with primary malignant brain tumors and their caregivers cope with the intense fear that their cancer might come back. The program involves 8 weekly one-on-one video sessions with a thera…

This study is testing a new approach to personalize treatment for people with a fast-growing brain tumor called glioblastoma. Researchers will use a lab test on tumor cells to see which drugs might work best for each patient. The goal is to find out if this method can help more p…

This study tracks mental health and suicide risk in 176 adults with glioblastoma, a serious brain cancer. Participants fill out questionnaires about depression, anxiety, quality of life, and suicidal thoughts. The goal is to understand what factors increase suicide risk in these …

This study tests whether a substance called 5-ALA, already used during brain surgery to make tumor cells glow, can also be detected in blood or urine. Researchers hope this 'liquid biopsy' could help diagnose and monitor glioblastoma, the most common and deadly brain tumor, witho…