GLIOBLASTOMA (GBM)

This study is testing whether a modified virus can help control recurrent glioblastoma, a very aggressive brain cancer. Researchers will inject the virus directly into the tumor to see if it can kill cancer cells and slow the disease. The trial will also carefully monitor partici…

This study is testing if adding a direct spinal fluid chemotherapy injection to standard brain cancer treatment helps adults with a particularly aggressive form of glioblastoma (GBM) that has spread to brain fluid spaces. The goal is to see if this combined approach can better co…

This study is testing whether adding a new immunotherapy called DOC1021 to the standard treatment helps adults newly diagnosed with glioblastoma live longer. About 180 participants will be randomly assigned to receive either the standard treatment alone or the standard treatment …

This study is testing whether giving a higher daily dose of radiation over three weeks works better than the standard dose for older adults with a newly diagnosed aggressive brain tumor called glioblastoma. Researchers will compare survival, side effects, and quality of life betw…

This study is testing if a drug called G-CSF (Filgrastim) can help protect the brain and preserve thinking skills in people with a specific type of brain cancer (MGMT-methylated glioblastoma) while they receive standard radiation and chemotherapy. Researchers want to see if addin…

This early-stage trial is testing a new type of stem cell treatment for people with a newly diagnosed, aggressive brain cancer called glioblastoma. The stem cells are modified to carry a 'suicide gene' and are injected directly into the brain after surgery. The main goal is to se…

This study is testing a more precise way to deliver radiation therapy to people with aggressive brain tumors called glioblastoma. Using a special machine that combines MRI scanning with radiation delivery, doctors can adjust the treatment daily to target the tumor more accurately…

This study is testing whether the time of day a brain cancer patient takes their chemotherapy pill matters. Researchers want to see if taking the drug, temozolomide, in the morning or evening is easier for patients to stick to and if it affects their quality of life or outcomes. …

This early-stage study is testing a new two-part treatment for a hard-to-treat brain cancer called glioblastoma. Doctors take a patient's own immune cells, arm them to target the cancer, and then use gentle sound waves to temporarily open the blood-brain barrier. The main goals a…

This global Phase 3 trial is testing whether adding a new targeted radiation therapy (TLX101-Tx) to standard chemotherapy (lomustine) works better than chemotherapy alone for adults whose aggressive brain cancer (glioblastoma) has returned for the first time. The new therapy aims…

This early-stage trial is testing a new targeted drug called risvutatug rezetecan in people with aggressive, recurrent brain cancers. It aims to see how much of the drug reaches the brain tumor and to check its safety. The study will enroll about 15 people with either recurrent g…

This study aims to develop and test a new blood test that uses artificial intelligence to detect cancer early and monitor how well treatment is working. Researchers will analyze RNA from blood cells in 6,000 participants, including people with 8 common cancers and healthy individ…

This study is testing a new psychological support program called FearLess, designed to help people with brain tumors and their caregivers manage the fear of the cancer coming back. Researchers want to see if the program is practical, acceptable, and a good fit for participants. T…

This study aims to see if a special fluorescent dye used during brain surgery can help create a blood test for glioblastoma, a very aggressive brain tumor. Researchers will collect blood and urine samples from about 30 patients before and after they receive the dye to measure its…