GLIOBLASTOMA (GBM)

This study tests a combination of two drugs—Lutathera (a targeted radiation therapy) and olaparib (a PARP inhibitor)—in children and teens aged 3 to 18 with solid tumors that have come back or not responded to standard treatment. The goal is to find the safest dose and see if the…

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with malignant brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal …

This study is for people with a newly diagnosed, aggressive brain cancer called glioblastoma that has a specific genetic change (MTAP deletion). The trial tests an experimental drug, BGB-58067, designed to target cancer cells while sparing healthy ones. The goal is to see if the …

This study tests whether a higher daily dose of radiation over three weeks can help adults aged 65 and older with newly diagnosed glioblastoma live longer and with fewer side effects compared to the standard three-week radiation course. About 56 participants will be randomly assi…

This early-phase trial tests an investigational drug called risvutatug rezetecan (GSK5764227) in 15 people with recurrent grade 4 glioma or brain metastases. The drug is designed to seek out and attack tumor cells while sparing healthy tissue. The study first checks how much drug…

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions: one helps a common drug kill cancer cells, and the other wakes up the immune system to attack…

This study tests a new way of giving radiation therapy to people with glioblastoma, a fast-growing brain tumor. The approach uses daily MRI scans to adjust the radiation beam precisely, allowing doctors to treat smaller areas with higher doses. The goal is to see if this method c…

This study tests whether adding a chemotherapy drug (thiotepa) injected into the spinal fluid can improve outcomes for people with glioblastoma that has spread to the brain's lining or fluid spaces. About 38 adults will receive surgery, radiation, and standard oral chemo plus the…

This study tests a new drug, TLX101-Tx, which delivers radiation directly to glioblastoma cells, combined with standard chemotherapy (lomustine) in 50 adults whose brain cancer has returned after initial treatment. The goal is to see if the combination helps control the tumor bet…

This study tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent glioblastoma from spreading to the lining of the brain and spine. About 38 adults with newly diagnosed glioblastoma that touches certain brain areas will receive the drug alo…

This early-phase trial tests a new treatment for glioblastoma, a fast-growing brain cancer. After standard surgery, patients receive a single dose of special stem cells that carry a 'suicide gene' directly into the tumor site. The goal is to see if this approach is safe and can k…

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule to deliver radiation directly to cancer cells. It is for adults aged 18-80 who have completed standard therapy but need extra treatment. …

This study tests whether adding silevertinib (an oral targeted therapy) to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. About 162 adults whose tumors have certain genetic markers (…

This study tests a new treatment called DOC1021, made from a patient's own immune cells, combined with standard therapy for newly diagnosed glioblastoma, an aggressive brain cancer. About 180 adults will either receive the immune therapy plus standard care or standard care alone.…

This early-phase trial tests a new treatment for a fast-growing brain cancer called glioblastoma. It combines a patient's own immune cells, trained to attack the cancer, with low-intensity ultrasound to temporarily open the blood-brain barrier. The goal is to see if this approach…

This study tests whether giving G-CSF (a drug that boosts white blood cells) alongside standard chemoradiation can help preserve brain structure and thinking abilities in people with a specific type of glioblastoma (MGMT-methylated). About 60 newly diagnosed patients will be rand…

This early-phase study tests a new drug called MT-125 given alongside standard radiation for people with a newly diagnosed, aggressive brain tumor called glioblastoma. The main goals are to find a safe dose and check for side effects. About 36 adults aged 18 and older with a spec…

This study tests a virus that targets cancer cells in people with recurrent glioblastoma, a severe brain cancer that has come back after standard treatments. About 20 participants will receive up to 6 injections of the virus directly into the tumor over several weeks. The main go…

This study looks at whether taking the chemotherapy drug temozolomide in the morning or evening is practical for people with glioblastoma, a type of brain cancer. About 50 adults who have already had surgery and radiation will be randomly assigned to take their medication either …

This study is testing whether a program called FearLess is practical and well-received by people with primary malignant brain tumors and their caregivers. The goal is to see if the recruitment methods, study design, and program itself work well before a larger trial. About 112 pa…

This study is testing whether a blood or urine test can detect signals from brain tumors, especially glioblastoma. Researchers will use a special dye (5-ALA) that makes tumor cells glow during surgery to help link what's seen in the blood to the actual tumor. The goal is to devel…

This study is developing an AI-powered blood test to find cancer early and see how well treatments are working. Researchers will analyze blood samples from 6,000 adults with or without cancer to identify unique RNA signals in platelets and immune cells. The goal is a safe, non-in…

This study looks at why some people with glioblastoma (a serious brain cancer) may feel depressed, anxious, or have thoughts of suicide. Researchers will ask 176 patients in Germany to fill out questionnaires about their mood, quality of life, and support from others. The goal is…