Brain cancer vaccine shows promise in new trial
NCT ID NCT06805305
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This phase 2 trial tests whether adding DOC1021, a personalized dendritic cell vaccine, to standard treatment (surgery, chemo, radiation) improves survival in adults newly diagnosed with glioblastoma. About 180 participants will be randomly assigned to receive the vaccine plus standard care or standard care alone. The study measures overall survival and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
DOC1021 dendritic cell vaccine
What this could lead to
If successful, this could offer a new treatment option that extends survival for people with glioblastoma, a highly aggressive brain cancer.
What could go wrong
This is a mid-stage trial with 180 participants, so results are not yet proven. The vaccine may not improve survival and could cause side effects like injection reactions or immune-related issues.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Atlantic Health
RECRUITINGSummit, New Jersey, 07901, United States
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Banner MD Anderson Cancer Center
ACTIVE_NOT_RECRUITINGGilbert, Arizona, 85234, United States
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Baptist MD Anderson Cancer Center
RECRUITINGJacksonville, Florida, 32207, United States
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77057, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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City of Hope
RECRUITINGDuarte, California, 91010, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cooper University Health Care
RECRUITINGCamden, New Jersey, 08103, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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HOAG
RECRUITINGNewport Beach, California, 92663, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Lenox Hill Hospital
RECRUITINGNew York, New York, 10075, United States
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Rutgers Cancer Institute
RECRUITINGNew Brunswick, New Jersey, 08901, United States
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The Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Texas Health Science Center at San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCSF
RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UNC Lineberger Comprehensive Cancer Center
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UPMC Presbyterian Hospital
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UTHealth Houston
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt-Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37203, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••