Brain cancer vaccine shows promise in new trial
NCT ID NCT06805305
First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 4 times
Summary
This phase 2 trial tests whether adding DOC1021, a personalized dendritic cell vaccine, to standard treatment (surgery, chemo, radiation) improves survival in adults newly diagnosed with glioblastoma. About 180 participants will be randomly assigned to receive the vaccine plus standard care or standard care alone. The study measures overall survival and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DOC1021 dendritic cell vaccine
- What this could lead to
- If successful, this could offer a new treatment option that extends survival for people with glioblastoma, a highly aggressive brain cancer.
- What could go wrong
- This is a mid-stage trial with 180 participants, so results are not yet proven. The vaccine may not improve survival and could cause side effects like injection reactions or immune-related issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for GLIOBLASTOMA (GBM) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Atlantic Health
RECRUITINGSummit, New Jersey, 07901, United States
-
Banner MD Anderson Cancer Center
ACTIVE_NOT_RECRUITINGGilbert, Arizona, 85234, United States
-
Baptist MD Anderson Cancer Center
RECRUITINGJacksonville, Florida, 32207, United States
-
Baylor College of Medicine
RECRUITINGHouston, Texas, 77057, United States
-
City of Hope
RECRUITINGDuarte, California, 91010, United States
Contact Email: •••••@•••••
-
Cooper University Health Care
RECRUITINGCamden, New Jersey, 08103, United States
-
Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Email: •••••@•••••
-
HOAG
RECRUITINGNewport Beach, California, 92663, United States
-
Lenox Hill Hospital
RECRUITINGNew York, New York, 10075, United States
-
Rutgers Cancer Institute
RECRUITINGNew Brunswick, New Jersey, 08901, United States
-
The Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
-
The University of Texas Health Science Center at San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
-
UCSF
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
-
UNC Lineberger Comprehensive Cancer Center
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Email: •••••@•••••
-
UPMC Presbyterian Hospital
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
-
UTHealth Houston
RECRUITINGHouston, Texas, 77030, United States
-
Vanderbilt-Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37203, United States
-
Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Custom-Made vaccine train the immune system to fight brain cancer?
- Can a virus injected into brain tumors fight recurrence?
- Can adding lenvatinib to standard care outsmart a tough brain cancer?
- Can a pill reach the brain and fight tumors?
- New drug combo targets Hard-to-Treat brain tumors
- Targeted radiation delivered directly to brain tumor cavity in new trial