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New drug combo targets Hard-to-Treat brain tumors

NCT ID NCT07708961

Not yet recruiting Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This clinical trial is testing whether adding an experimental drug called WSD0922-FU to standard chemotherapy (temozolomide) can better slow the growth of a specific type of brain cancer called EGFR-mutant glioblastoma. The study involves about 60 adults whose tumors have a particular genetic change. WSD0922-FU is designed to block a protein that helps these cancer cells grow, and it can reach the brain and spinal cord. The main goal is to see if the combination delays disease progression compared to chemotherapy alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a drug called WSD0922-FU that blocks EGFR, combined with the chemotherapy temozolomide
What this could lead to
If successful, this combination could offer a new, more effective treatment option for people with a specific type of glioblastoma, potentially slowing tumor growth and extending life.
What could go wrong
This is a phase II trial with only 60 participants, so results are preliminary. The drug may cause side effects, and it is not yet known if it will meaningfully improve outcomes over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma IDH-wildtype glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA, IDH-WILDTYPE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, 85259, United States

    Contact Phone: •••-•••-••••

    Contact

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

    Contact Phone: •••-•••-••••

    Contact

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

    Contact Phone: •••-•••-••••

    Contact

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