Spinal chemotherapy may block deadly brain cancer spread

This phase 2 trial tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent glioblastoma from spreading to the brain and spinal cord lining. The study enrolls 38 newly diagnosed patients whose tumors touch brain fluid spaces or whose surgery accidentally opened those spaces. Participants receive standard treatment plus six weekly spinal injections of thiotepa, and researchers will track survival and side effects for two years.