GLIOBLASTOMA (GBM)

This study tests a new way to give radiation therapy to people under 70 with a fast-growing brain tumor called glioblastoma. Instead of many small doses of radiation, patients will receive fewer but stronger doses along with the chemotherapy drug temozolomide. The goal is to see …

This study tests whether using a smaller radiation area after glioblastoma surgery can control tumor growth while causing fewer side effects. About 79 adults aged 18-70 who had surgery for this aggressive brain cancer will receive radiation to a 1 cm margin around the original tu…

This early-stage study tests a new drug called FZ-AD005 in about 40 people with aggressive brain tumors (high-grade glioma) that have come back or not responded to treatment. The drug is designed to target and attack cancer cells. The main goals are to find a safe dose and see if…

This early-phase trial tests a new type of immune cell therapy (CAR-T) for people with recurrent glioblastoma, an aggressive brain cancer. The therapy is designed to target a specific protein (EGFRvIII) found on cancer cells and includes a metabolic boost to help the cells work b…

This study tests whether adding a shingles vaccine and, in some cases, specially grown immune cells to standard treatment can help people with glioblastoma live longer. About 230 adults with this aggressive brain cancer will receive the vaccine after surgery, radiation, and chemo…

This early-stage trial tests a new drug, STAR-001, combined with spironolactone in about 68 people whose glioblastoma has returned after initial treatment. The goal is to see if the combination is safe and can shrink tumors. Participants receive STAR-001 by IV twice per cycle and…

This study tests a stepped-care program to support relatives of people with serious brain injuries or tumors. The program offers information, screening, and extra help based on each caregiver's needs. 160 relatives will either receive this support or usual care. The goal is to re…

This study tests a special microscope attachment (GLOW400) that helps surgeons see glowing brain tumors during surgery. About 37 adults with suspected high-grade gliomas will take part. The goal is to check if the tool provides clear images and is safe to use. It is an observatio…

This study looks at whether male hormones (androgens) affect the immune environment around glioblastoma, the most common and aggressive brain cancer in adults. Researchers will analyze tumor and blood samples from 40 newly diagnosed patients aged 18 to 55. The goal is to understa…