New hope for aggressive brain tumors: experimental combo targets first recurrence

NCT ID NCT07431216

First seen Feb 25, 2026 · Last updated May 07, 2026 · Updated 6 times

Summary

This early-stage trial tests a new drug, STAR-001, combined with the old blood-pressure medicine spironolactone in about 68 adults whose glioblastoma (a fast-growing brain cancer) has come back after initial treatment. The goal is to see if the combination is safe and can shrink tumors. Participants receive STAR-001 by IV twice per 3-week cycle and take spironolactone pills before each infusion.

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