Can a higher radiation dose help older brain cancer patients live longer?

NCT ID NCT06835803

Recruiting now Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether a higher daily dose of radiation over three weeks is better than the standard dose for people aged 65 and older with newly diagnosed glioblastoma, an aggressive brain cancer. About 56 participants will be randomly assigned to one of two radiation schedules. The study will compare survival, tumor control, side effects, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy
What this could lead to: If successful, this could show that a higher daily radiation dose over three weeks improves survival and tumor control for older adults with glioblastoma.
What could go wrong: This is a small early-phase trial (56 participants) and may not prove effective. Higher radiation doses could also increase side effects like brain swelling or fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA (GBM)

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Dana-Farber Brigham Cancer Center, Milford Hospital
RECRUITING

Milford, Massachusetts, 01757, United States
Dana-Farber Brigham Cancer Center, South Shore Hospital
RECRUITING

South Weymouth, Massachusetts, 02190, United States

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