Can a common white blood cell booster shield the brain from Chemo-Radiation damage?
NCT ID NCT06649851
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 pilot study tests whether granulocyte colony stimulating factor (G-CSF), a drug that boosts white blood cells, can help preserve brain structure and thinking skills in people with a specific type of glioblastoma (MGMT-methylated) undergoing standard chemoradiation. About 60 newly diagnosed patients will receive either G-CSF plus standard treatment or standard treatment alone. The study measures brain volume changes on MRI and cognitive function over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Granulocyte colony stimulating factor (G-CSF, also called Filgrastim)
- What this could lead to
- If it works, this could point toward a way to reduce brain damage and cognitive decline from standard chemoradiation in glioblastoma patients.
- What could go wrong
- This is a small early-phase pilot study with only 60 participants, so results may not be conclusive. G-CSF may not provide meaningful brain protection, and side effects from the drug or chemoradiation remain possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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