Two-Pronged gene therapy takes on deadly brain tumors

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions: one helps a common drug kill cancer cells, and the other wakes up the immune system to attack the tumor. About 68 adults aged 18-70 will receive a single injection of TGX-007 into their tumor, followed by a short course of an antiviral pill, before standard surgery. The study aims to find the safest and most effective dose and to see if it helps people live longer.