Can a modified herpes virus fight recurrent brain tumors?
NCT ID NCT05235074
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial is testing an experimental treatment called OH2, a modified herpes simplex virus, for people with recurrent central nervous system tumors, including glioblastoma. The virus is injected into the tumor cavity after surgery to see if it can safely attack cancer cells and slow tumor growth. The study involves two phases: first to find the safest dose, then to evaluate how well it works. Participants are adults with confirmed recurrent brain tumors who have had surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- OH2 injection, an oncolytic type 2 herpes simplex virus
- What this could lead to
- If successful, this approach could offer a new treatment option for recurrent brain tumors, potentially slowing disease progression and extending survival.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the benefits are uncertain. There are risks of side effects from the virus, and the treatment may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CENTRAL NERVOUS SYSTEM TUMORS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, 100070, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A simple lotion duo may shield skin from Tumor-Treating fields
- Can a new pill take on brain cancer?
- Can a special MRI reveal hidden brain tumors and guide a stronger radiation strike?
- Radioactive beads take aim at brain tumours
- Two-Drug combo aims to outsmart recurrent brain tumors
- Gene-Edited immune cells take on aggressive brain tumors