Can a special MRI reveal hidden brain tumors and guide a stronger radiation strike?

NCT ID NCT05284643

Recruiting now Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This pilot trial is testing whether an advanced MRI technique called spectroscopic MRI (sMRI) can uncover hidden areas of recurrent glioblastoma that standard scans miss. Using that information, doctors will deliver a higher dose of proton radiation directly to the tumor, along with the drug bevacizumab to help protect healthy brain tissue. The goal is to see if this more targeted approach can kill more cancer cells while keeping side effects manageable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a combination of proton radiation therapy and the drug bevacizumab (Avastin)
What this could lead to: If successful, this approach could offer a more precise way to treat recurrent glioblastoma, potentially improving tumor control and survival.
What could go wrong: This is an early pilot trial, so the benefits are uncertain. Higher radiation doses may increase the risk of serious neurological side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer glioblastoma gliosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT GLIOBLASTOMA

Contacts and locations

Locations

University of Miami
RECRUITING

Miami, Florida, 33136, United States

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