Two-Drug combo aims to outsmart recurrent brain tumors
NCT ID NCT02974621
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This trial compares a combination of two drugs (cediranib and olaparib) against a single drug (bevacizumab) in people whose glioblastoma has returned after prior treatment. The goal is to see if the combination can delay tumor growth better than the standard approach. Participants must have already received radiotherapy and temozolomide.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cediranib maleate and olaparib (tablets) compared to bevacizumab (intravenous infusion)
- What this could lead to
- If successful, this combination could offer a new treatment option for recurrent glioblastoma, potentially slowing tumor growth better than current standard therapy.
- What could go wrong
- This is a phase 2 trial with only 70 participants, so results may not apply to all patients. The combination may cause more side effects than bevacizumab alone, and it may not improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
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Siteman Cancer Center at Christian Hospital
St Louis, Missouri, 63136, United States
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Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
St Louis, Missouri, 63129, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437, United States
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Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385, United States
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Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105, United States
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Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, 06824, United States
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Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611, United States
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Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, 06418, United States
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Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut, 06477, United States
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Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, 06790, United States
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Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, 06708, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale University
New Haven, Connecticut, 06520, United States
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