Sound waves may help chemo reach deadly childhood brain tumors

NCT ID NCT05630209

First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 25 times

Summary

This study tests whether a special ultrasound device can safely open the blood-brain barrier in children with a rare, aggressive brain tumor called DIPG. By temporarily allowing the chemotherapy drug doxorubicin to reach the tumor, researchers hope to improve treatment. The study involves 10 children aged 5 to 21 and focuses on safety and how well the barrier opens.

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Contacts and locations

Locations

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Cook Children's Health Care System

    Fort Worth, Texas, 76104, United States

  • Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm diffuse intrinsic pontine glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.