BRAIN TUMOR

This early-stage trial tested a new drug called CUDC-907 in 26 children and young adults (ages 1-21) whose solid tumors, brain tumors, or lymphoma had stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. Researchers also …

This early-phase trial tested whether adding two drugs—pembrolizumab (an immunotherapy) and vorinostat (a targeted drug)—to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. The study enrolled 21 adults and focus…

This small pilot study tested a device called NaviFUS that uses focused ultrasound waves, combined with the standard drug bevacizumab, in 6 adults whose glioblastoma brain tumor had returned after prior treatment. The goal was to see if the combination was safe and could help con…

This study tested a new MRI contrast agent called RVP-001, which does not contain gadolinium, in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and effective at highlighting these lesions compared to standard gado…

This early study tested a new imaging technique that combines a special tracer called [18F]PARPi with PET/MR scans to take clearer pictures of brain tumors. Five adults with new or suspected returning brain tumors took part. The goal was to see how well the tracer highlights tumo…

This study looked at whether a type of PET scan (FDOPA-PET) can help doctors tell the difference between brain tumors and non-cancerous brain lesions. Researchers analyzed scans from 74 patients with suspected brain tumors. The goal was to find patterns in the scan that best sepa…

This study tested whether a sedative called dexmedetomidine can protect the brain during surgery to remove a brain tumor. 56 adults having brain tumor surgery received either the drug or a placebo. The researchers measured markers of brain injury and oxygen use to see if the drug…

This study tested a special counseling program called CALM (Managing Cancer and Living Meaningfully) for people with brain cancer. 60 participants were split into two groups: one received CALM plus usual care, the other just usual care. The goal was to see if CALM is practical an…

This study tested whether watching 360° virtual reality movies can help lower fear and anxiety in cancer patients before they start radiation treatment. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched VR movies and then…

This study looked at whether a 12-week physical activity program could improve memory and attention in children ages 8-17 who had radiation for a brain tumor at least a year earlier. 36 children participated, with some starting the program right away and others after a delay. The…

This study tested a new telehealth program called C-SMART for people with brain tumors who have mild memory or thinking problems. The goal was to see if the program was practical and acceptable for patients and their caregivers. 32 people took part, and researchers measured how m…

This study gathered medical information and biological samples from over 1,200 people with brain or spinal cord tumors. The goal was to learn more about these cancers and identify new areas for research. Participants provided blood, tissue, and other samples, and completed survey…

This study followed 155 children who had proton radiation for brain or central nervous system tumors. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment. The goal was to understand long-term effects, n…

This study looked at whether online training can improve how well emergency department doctors interpret CT head scans. 173 clinicians from 6 UK hospitals took part. One group received training right away, while a control group got it later. Their scan readings were compared to o…

This study tested a new, highly sensitive ultrasound technique to map brain activity during surgery in 23 adults with brain tumors or lesions. The goal was to see if this method could show which brain areas are active, helping surgeons avoid damaging important regions. The approa…