Sound waves may help deliver brain tumor drug
NCT ID NCT04446416
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested a device called NaviFUS that uses focused ultrasound to temporarily open the blood-brain barrier, combined with the drug bevacizumab (Avastin), in 6 patients with recurrent glioblastoma (a type of brain cancer). The goal was to see if the combination is safe and can slow tumor growth. Patients received the treatment after standard therapies had failed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Bevacizumab (Avastin) combined with focused ultrasound (NaviFUS system)
- What this could lead to
- If successful, this approach could offer a new way to deliver drugs to brain tumors by temporarily opening the blood-brain barrier, potentially improving treatment for recurrent glioblastoma.
- What could go wrong
- This is a very early pilot study with only 6 participants, so results may not apply to a larger population. The treatment may not improve survival or could cause side effects from the ultrasound or drug.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Linkou Chang Gung Memorial Hospital
Taoyuan City, 33305, Taiwan
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