New hope for glioblastoma: phase 3 trial pits niraparib against standard chemo

NCT ID NCT06388733

Ongoing Disease control Sponsor: Ivy Brain Tumor Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This Phase 3 trial compares the drug niraparib to the standard chemo temozolomide in 450 adults with newly diagnosed, aggressive glioblastoma that has a specific genetic marker (MGMT unmethylated). Participants take the assigned drug daily during radiation, then continue until the cancer worsens or for up to 6 cycles. The main goal is to see if niraparib helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: niraparib (Zejula)
What this could lead to: If niraparib works better than temozolomide, it could become a new standard treatment for this aggressive brain cancer, potentially extending survival.
What could go wrong: This is a large Phase 3 trial, but glioblastoma is very hard to treat. Niraparib may not improve survival over the current drug, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioblastoma glioma susceptibility 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN NEOPLASMS, ADULT, MALIGNANT BRAIN TUMOR GBM GLIOBLASTOMA

Contacts and locations

Locations

A.S.L. Napoli 1 Centro Ospedale del Mare

Naples, Napoli, 80147, Italy
Addenbrooke's Hospital

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Allina Health

Minneapolis, Minnesota, 55407, United States
Atlantic Health System

Summit, New Jersey, 07901, United States
Austin Health

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera Universitaria Careggi

Florence, Firenze, 50134, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza

Rome, Roma, 00161, Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino

Torino, Torino, 10124, Italy
BC Cancer - Vancouver

Vancouver, British Columbia, V5Z 4E6, Canada
Baylor Scott & White Health

Temple, Texas, 76508, United States
Bayside Health (formerly The Alfred Hospital)

Melbourne, Victoria, 3004, Australia
Beatson West of Scotland Cancer Centre

Glasgow, Strathclyde, G12 0YN, United Kingdom
Bristol Haematology and Oncology Centre

Bristol, Avon, BS2 8ED, United Kingdom
CHU Amiens-Picardie - Site Sud

Amiens, Somme, 80054, France
CHU Nice - Hôpital Pasteur

Nice, Alpes Maritimes, 06001, France
CHUM (Centre hospitalier de l'Université de Montréal)

Montreal, Quebec, H2X 0C1, Canada
CRLCC Eugene Marquis

Rennes, Ille et Vilaine, 35000, France
Centre Georges François Leclerc

Dijon, 21079, France
Centre Hospitalier Universitaire de Lyon-Hospices Civils de Lyon-Hopital Pierre Wertheimer

Bron, Rhone, 69500, France
Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada
Centre Leon Berard

Lyon, Rhone, 69008, France
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Duke Cancer Center Brain Tumor Clinic

Durham, North Carolina, 27710, United States
Ente Ospedaliero Cantonale

Bellinzona, 6500, Switzerland
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, Milano, 20133, Italy
Groupe Hospitalier Pitie-Salpetriere

Paris, Paris, 75013, France
Guy's Hospital

London, SE1 9RT, United Kingdom
Hospital Clinic de Barcelona

Barcelona, Barcelona, 08036, Spain
Hospital Clinico Universitario de Salamanca

Salamanca, Salamanca, 37370, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, 28041, Spain
Hospital Universitario HM Madrid Sanchinarro

Madrid, Madrid, 28050, Spain
Hospital Universitario Ramon y Cajal

Madrid, Madrid, 28034, Spain
Hospital Universitario Reina Sofia

Córdoba, Córdoba, 14004, Spain
Hospital Universitario Virgen del Rocio

Seville, Sevilla, 41013, Spain
Hospital del Mar

Barcelona, Barcelona, 08003, Spain
Hôpital de la Timone

Marseille, Bouches-du-Rhône, 13385, France
ICO - Site René Gauducheau

Saint-Herblain, Loire Atlantique, 44800, France
ICO Girona - Hospital Universitari de Girona Dr Josep Trueta

Girona, Girona, 17007, Spain
ICO l'Hospitalet - Hospital Duran i Reynals

Barcelona, 08906, Spain
IOV - Istituto Oncologico Veneto IRCCS

Padova, Padova, 35128, Italy
IRCCS Istituto delle Scienze Neurologiche di Bologna

Bologna, Bologna, 40139, Italy
Indiana University

Indianapolis, Indiana, 46202, United States
Inselspital - Universitaetsspital Bern

Bern, 3010, Switzerland
Institut du Cancer de Montpellier

Montpellier, Herault, 34298, France
Istituto Clinico Humanitas

Rozzano, Milano, 20089, Italy
Ivy Brain Tumor Center

Phoenix, Arizona, 85013, United States
Jersey Shore University Medical Center

Neptune City, New Jersey, 07753, United States
Klinikum Chemnitz gGmbH

Chemnitz, Saxony, 09116, Germany
Maastricht UMC

Maastricht, 6229 HX, Netherlands
MaineHealth Maine Medical Center Care

South Portland, Maine, 04106, United States
Medical University of South Carolina - Department of Neurosurgery

Charleston, South Carolina, 29425, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
Moores UCSD Cancer Center

La Jolla, California, 92093, United States
New York University Ambulatory Care Center

New York, New York, 10016, United States
Northwell Health

New Hyde Park, New York, 11042, United States
Oslo Universitetssykehus HF, Radiumhospitalet

Oslo, 0379, Norway
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Queen Elizabeth Hospital

Birmingham, West Midlands, B15 2TH, United Kingdom
Saint Lukes Neuro Oncology

Kansas City, Missouri, 64111, United States
Scripps Cancer Center

La Jolla, California, 92037, United States
Smilow Cancer Hospital at Yale New Haven

Guilford, Connecticut, 06437, United States
St Vincent's Hospital Melbourne

Fitzroy, Victoria, 3065, Australia
St. Olavs Hospital Hf, Universitetssykehuset i Trondheim

Trondheim, 7030, Norway
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
The Christie Hospital

Manchester, Greater Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre

Metropolitan Borough of Wirral, Merseyside, CH63 4JY, United Kingdom
The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
The NeuroMedical Center

Baton Rouge, Louisiana, 70809, United States
The Ohio State University

Columbus, Ohio, 43210, United States
The University of Vermont Medical Center

Burlington, Vermont, 05401, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UMC Utrecht

Utrecht, 3584 CX, Netherlands
Universitaetsklinikum Bonn AoeR

Bonn, North Rhine-Westphalia, 53127, Germany
Universitaetsklinikum Heidelberg

Heidelberg, Baden-Wurttemberg, 69120, Germany
Universitaetsklinikum Leipzig

Leipzig, Saxony, 04103, Germany
Universitaetsklinikum Regensburg

Regensburg, Bavaria, 93053, Germany
Universitaetsklinikum Tuebingen

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsmedizin Mannheim

Mannheim, Baden-Wurttemberg, 68167, Germany
Universitaetsspital Basel

Basel, 4031, Switzerland
Universitaetsspital Zürich

Zurich, 8091, Switzerland
University Health Network - Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of Cincinnati Cancer Institute

Cincinnati, Ohio, 45267, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Minnesota Health Clinics and Surgery Center, Minneapolis

Minneapolis, Minnesota, 55455, United States
University of Pittsburgh Medical Center Health System

Pittsburgh, Pennsylvania, 15232, United States
University of Washington Medical Center

Seattle, Washington, 98109, United States
University of Wisconsin Cancer Center

Madison, Wisconsin, 53706, United States
Velindre Cancer Centre

Cardiff, South Glamorgan, CF14 2TL, United Kingdom
Vivantes Klinikum Neukoelln

Berlin, State of Berlin, 12351, Germany
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States
Washington University, School of Medicine

St Louis, Missouri, 63110, United States

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