Breast cancer drug could help fight brain tumors
NCT ID NCT03122197
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests whether letrozole, a drug normally used for breast cancer, can reach and concentrate in recurrent high-grade gliomas (aggressive brain tumors). About 39 adults will take letrozole pills daily along with standard temozolomide chemotherapy. Researchers will measure how much letrozole gets into the tumor and track side effects and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Letrozole (Femara) and Temozolomide (Temodar)
What this could lead to
If it works, this could point toward a new way to treat recurrent high-grade gliomas by combining letrozole with standard chemotherapy.
What could go wrong
This is a very early, small trial (39 people) focused on drug levels and safety, not yet on effectiveness. The drug may not reach tumors enough or may cause side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45267, United States
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