University Of Cincinnati

This study tests whether combining radiation therapy (either standard X-ray or proton beam) with an immunotherapy drug (pembrolizumab) before surgery is safe and effective for people with recurrent head and neck cancer. About 40 participants will receive the combination treatment…

This study compares two types of metal plates used to fix a broken hip socket after a dislocation. The goal is to see which plate helps the bone heal better and lowers the chance of early arthritis. About 60 adults aged 18-65 who need surgery within two weeks of injury will take …

This study looks at whether a procedure called endovascular thrombectomy (EVT) helps people who already have a moderate-to-severe disability and then have a major stroke. About 1,060 adults will be randomly assigned to get EVT or standard medical care. The goal is to see if EVT i…

This study tests an injection called AM3101 given during knee surgery for a torn meniscus. The goal is to see if it helps the tear heal better and reduces the need for more surgery. About 74 adults aged 18 to 40 will take part, and half will get the study drug while the other hal…

This study tests whether using a brain wave monitor to guide a step-by-step treatment plan can reduce harmful electrical events after severe traumatic brain injury. About 72 adults who need emergency brain surgery will be randomly assigned to standard care or the monitor-guided a…

This study tests a new device called VirtuaCare™ that gives patients step-by-step instructions and real-time feedback on their shoulder exercises at home. The goal is to see if it helps people recovering from shoulder replacement or rotator cuff repair stick to their prescribed p…

This study looks at whether a supplement called N-acetylcysteine (NAC) and mindfulness-based therapy can help young people aged 15 to 24 with mild depression. Researchers will measure changes in brain chemicals and connections linked to emotion and attention. The goal is to find …

This study looks at whether moderate or high-intensity walking exercise is better for improving walking in people who had a stroke at least 6 months ago. About 156 participants will be randomly assigned to one of two exercise programs, each done with a physical therapist three ti…

This study looks at whether using a continuous passive motion (CPM) machine after surgery for specific leg fractures can lower pain and the need for strong painkillers. About 100 adults who have had surgery for a broken hip socket, thigh bone, or shin bone will be split into two …

This study tests a new type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better and with fewer side effects than standard radiation. About 37 adults with advanced solid tumors will receive this treatme…

This study compares two standard pain-block methods for women having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers …

This study tests if doing tongue endurance exercises at home for 8 weeks can improve swallowing in adults who had a stroke 3-6 months ago. 70 participants will be randomly assigned to either the real exercise or a sham therapy. The goal is to see if the exercises strengthen tongu…

This study is testing whether starting pelvic floor physical therapy soon after radiation treatment can reduce bowel and bladder control problems in women with cervical cancer. About 28 women will receive the therapy and be checked for incontinence three months later. The goal is…

This study tests whether a probiotic called Pendulum Glucose Control (PGC) can be safely taken by patients receiving pelvic radiation for cancers like prostate, gynecologic, or lower GI cancers. The goal is to see if the probiotic helps reduce gastrointestinal side effects from r…

This early-phase study tests whether letrozole, a drug used for breast cancer, can get into brain tumors and work with standard treatments. About 39 adults with recurrent high-grade gliomas will take letrozole before surgery to measure drug levels in tumor tissue. The goal is to …

This study is testing whether brain scans and a technique called transcranial magnetic stimulation can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is to …

This early-stage study looks at how a protein called C-peptide might help the liver release sugar during low blood sugar (hypoglycemia) in people with type 1 diabetes. About 38 adults with type 1 diabetes will take part to see if C-peptide can boost glucagon, a hormone that raise…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity. T…

This study looks at how stroke affects walking efficiency. Researchers will test a new method to measure the energy used during walking in 18 people who have had a stroke. Participants will walk on a treadmill for three short sessions. The goal is to see if this new measure can h…

This study looks at how hormones change after a meal in people with cystic fibrosis. Researchers want to find links to blood sugar issues common in this group. About 61 adults aged 18-45 with cystic fibrosis will take part. No treatment is given; the goal is to learn more about t…

This study compares two forms of DHA (a healthy fat found in fish oil) in 153 older adults with early memory decline. One form (LPC-DHA) is thought to enter the brain more easily than standard DHA. Participants take supplements for 24 weeks, and researchers measure DHA levels in …