University Of Cincinnati

This study looks at whether a procedure to remove blood clots from the brain (endovascular thrombectomy) is better than standard medical care for people who have a stroke but already had a moderate-to-severe disability before the stroke. About 1,060 adults with a large-vessel blo…

This study tests a new treatment called AM3101 to help heal torn meniscus (knee cartilage) after surgery. About 74 people aged 18-40 with a meniscus tear will receive either AM3101 or a placebo injection during their operation. The goal is to see if AM3101 improves healing and re…

This study tests whether using a brain wave monitor to guide a step-by-step treatment plan can reduce harmful electrical events after severe traumatic brain injury. About 72 adults who need emergency brain surgery will be randomly assigned to standard care or the monitor-guided a…

This study is for people whose head and neck cancer has come back after previous treatment. It tests whether giving a type of radiation (either standard X-ray or proton) along with an immunotherapy drug (pembrolizumab) before surgery is safe and helps remove more of the tumor. Th…

This study compares two types of metal plates used to fix a broken hip socket (acetabular fracture). The goal is to see if a newer 'rim plate' with screws helps the bone heal better and lowers the chance of arthritis compared to the standard 'buttress plate'. The study will enrol…

This study is testing whether starting pelvic floor physical therapy soon after radiation treatment can reduce bowel and bladder control problems in women with cervical cancer. About 28 women will receive the therapy and be checked for incontinence three months later. The goal is…

This study compares two standard numbing methods for people having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other uses numbing medicine during surgery. The goal is to see which approach leads to less pain a…

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it shrinks tumors better than standard radiation and helps patients feel better. About 37 adults with advanced solid tumors will receive this tre…

This study looks at whether using a continuous passive motion (CPM) machine after surgery for certain leg fractures helps reduce pain and the need for strong painkillers. About 100 adults who have had surgery for a broken hip, thigh, or shin bone will be split into two groups: on…

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have trouble swallowing after a stroke. About 70 participants will be randomly assigned to do either tongue exercises or a sham therapy at home for 8 weeks. Researchers will measure …

This study tests whether a probiotic called Pendulum Glucose Control (PGC) can be safely taken by patients receiving pelvic radiation for cancers like prostate, gynecologic, or lower GI cancers. The goal is to see if the probiotic helps reduce gastrointestinal side effects from r…

This study looks at whether moderate or high-intensity walking exercise is better for improving walking in people who had a stroke at least 6 months ago. About 156 participants will be randomly assigned to one of two exercise programs, each done with a physical therapist three ti…

This study looks at whether a common supplement (N-acetylcysteine) and mindfulness-based therapy can improve mild depression in people aged 15 to 24. Researchers will measure changes in brain chemicals and connections linked to emotion and attention. The goal is to find better, d…

This early-phase study tests whether a naturally occurring protein, C-peptide, can help the liver produce more sugar during insulin-induced low blood sugar (hypoglycemia) in people with type 1 diabetes. Researchers will measure hormone levels and liver sugar production in 38 adul…

This study explores how signals from the body to the brain affect major depressive disorder (MDD). Researchers will use a non-invasive spinal cord stimulation technique in 67 adults with MDD to see if it changes brain activity related to mood. The goal is to understand these path…

This study looks at how hormone levels change after a meal in people with cystic fibrosis. The goal is to find patterns linked to blood sugar problems that often lead to diabetes. About 61 adults with cystic fibrosis will have their blood tested after drinking a special meal. No …

This early-phase study tests whether letrozole, a drug used for breast cancer, can get into brain tumors when combined with standard treatments. About 39 adults with recurrent high-grade gliomas will take letrozole before surgery, and researchers will measure drug levels in tumor…

This study looks at how stroke affects walking efficiency. Researchers will test a new method to pinpoint why walking is harder for some people. 18 adults with chronic stroke will walk on a treadmill to compare this new measure with standard energy-use tests.

This study compares two types of DHA (a healthy fat) in 153 older adults with early memory problems. One type (LPC-DHA) may get into the brain more easily than standard DHA. Researchers will measure DHA levels in spinal fluid and blood, along with brain health markers, over 24 we…

This study aims to find reliable tests that can predict how well a person's arm will recover after a stroke. Researchers will use brain scans and a safe, non-invasive brain stimulation technique on about 657 stroke patients within days of their stroke. The goal is to create bette…