University Of Cincinnati

This study is testing whether combining radiation therapy (proton or X-ray) with the immunotherapy drug pembrolizumab before surgery is safe and effective for people with recurrent head and neck cancer. The trial has two phases: the first checks safety and the right dose, and the…

This study tests an injectable drug called AM3101 to see if it can improve healing of meniscus tears in the knee after surgical repair. About 74 people aged 18 to 40 with a torn meniscus will be randomly assigned to receive either AM3101 or a saline placebo during surgery. The tr…

This study compares two ways to fix a broken hip socket using metal plates. One method uses a rim plate with screws through it, the other uses a buttress plate without those screws. Researchers will track 60 adults aged 18-65 to see which approach leads to better bone healing, le…

This early-phase trial tests whether letrozole, a drug normally used for breast cancer, can reach and concentrate in recurrent high-grade gliomas (aggressive brain tumors). About 39 adults will take letrozole pills daily along with standard temozolomide chemotherapy. Researchers …

This study looks at whether removing a large blood clot from the brain (endovascular thrombectomy) is better than standard medical care for stroke patients who already had a moderate-to-severe disability before their stroke. About 1,060 adults with a recent stroke and a pre-exist…

This study tests whether a special omega-3 supplement called Lysoveta can deliver more DHA to the brain than standard fish oil. Researchers will measure DHA levels in spinal fluid and blood, along with memory and thinking tests, in 153 older adults with early signs of memory decl…

This study looks at whether using a continuous passive motion (CPM) machine—a device that gently moves the leg—can help control pain and reduce the need for strong painkillers after surgery for certain leg fractures. About 100 adults who have had surgery for a broken hip socket, …

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better than standard radiation and help people feel better. About 37 adults with advanced solid tumors will receive this tre…

This study tests whether high-intensity interval training (short bursts of fast walking) is better than moderate-intensity walking for improving walking ability in people who had a stroke at least 6 months ago. 156 participants will be randomly assigned to one of two 12-week exer…

This study tests a new device called VirtuaCare™ that gives patients real-time feedback on their at-home shoulder exercises. Researchers want to see if it helps people recovering from shoulder replacement or rotator cuff repair do their prescribed exercises more consistently. Abo…

This study tests whether pelvic floor physical therapy can reduce bowel and bladder control problems that often happen after radiation for cervical cancer. Twenty-eight women who are getting pelvic radiation will start physical therapy four weeks after finishing radiation. The th…

This study tests whether a supplement called N-acetylcysteine (NAC) and mindfulness-based therapy can help young people aged 15 to 24 with mild depression. Participants will take NAC or a placebo and attend mindfulness or sham therapy sessions for 8 weeks. The goal is to see if t…

This study tests whether a daily probiotic pill (Pendulum Glucose Control) can safely reduce stomach and bowel problems in people receiving radiation for cancers of the pelvis, such as prostate, gynecologic, or lower GI cancers. About 20 adults will take the probiotic during thei…

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have had a stroke. Seventy participants will be randomly assigned to either the tongue exercise group or a sham therapy group. They will do home-based exercises for 8 weeks and have …

This study compares two standard pain-block methods for people having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers…

This study tests whether using nerve monitoring tools during breast cancer lymph node removal can help surgeons identify and protect nerves that often cause long-term pain. Six women with breast cancer will have the procedure, and researchers will check if the nerve signals can b…

This study looks at how brain activity changes as people recover from a moderate to severe traumatic brain injury (TBI). It also tests whether giving a gentle electrical stimulation to the brain (called anodal transcranial electrical stimulation) early after injury can improve th…

This study uses brain imaging to understand how a computer-based grammar program affects brain connections in preschoolers with Developmental Language Disorder (DLD). Researchers will scan children's brains before and after therapy to see changes in memory and language networks. …

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity an…

This study tests a new way to measure walking efficiency in people who have had a stroke. Researchers will have 18 participants walk on a treadmill, including a resisted walking trial, to see if a biomechanical measure can pinpoint movement problems better than current methods. T…

This study looks at how hormone levels change after a mixed meal in people with cystic fibrosis. Researchers want to find links to blood sugar problems common in this condition. About 61 adults aged 18-45 with cystic fibrosis will participate. No treatment is given; this is an ob…

This early study tests whether a natural protein called C-peptide can help the liver produce more sugar during insulin-induced low blood sugar in people with type 1 diabetes. Researchers will give C-peptide or a placebo to 38 volunteers and measure glucagon levels and liver sugar…

This study looks at whether monitoring specific brain wave patterns (called spreading depolarizations) in real time can help doctors choose treatments to reduce these events after severe traumatic brain injury. About 72 people who need emergency brain surgery will be randomly ass…

This study aims to see if brain scans and a technique called transcranial magnetic stimulation (TMS) can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is t…