Can a clot-busting procedure help stroke patients with prior disabilities?

NCT ID NCT05911568

Recruiting now Disease control Sponsor: University of Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether removing a large blood clot from the brain (endovascular thrombectomy) is better than standard medical care for stroke patients who already had a moderate-to-severe disability before their stroke. About 1,060 adults with a recent stroke and a pre-existing disability will be randomly assigned to either get the clot removal procedure or not. The goal is to see which approach leads to better recovery or survival.

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE STROKE, ACUTE STROKE, ISCHEMIC

Contacts and locations

Locations

Baptist Memorial Hospital
RECRUITING

Memphis, Tennessee, 38120, United States
Barnes Jewish Hospital
RECRUITING

Saint Loius, Missouri, 63110, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Hartford Health Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
HonorHealth
RECRUITING

Phoenix, Arizona, 85013, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Kaiser Permanente Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90027, United States
New York University
RECRUITING

Brooklyn, New York, 11220, United States
Providence St. Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States
Standford
RECRUITING

Palo Alto, California, 94305, United States
Swedish Medical Center
RECRUITING

Englewood, Colorado, 80113, United States
University of California at Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Cincinnati San Diego
RECRUITING

San Diego, California, 92121, United States
University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
University of Miami
RECRUITING

Miami, Florida, 33125, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Texas at Austin
RECRUITING

Austin, Texas, 78712, United States
University of Washington
RECRUITING

Seattle, Washington, 98104, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States
Yale University
RECRUITING

New Haven, Connecticut, 06510, United States

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